Ethanol-induced inhibition of chick brain growth.
Ethanol-induced inhibition of chick brain growth.
复制标题
乙醇诱导的对小鸡大脑生长的抑制。
DOI：
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发表时间：
1984
期刊：
影响因子：
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通讯作者：
S. Pennington
中科院分区：
文献类型：
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作者：
J. Boyd;G. Kalmus;S. Pennington
胎儿大脑发育迟缓与慢性酗酒母亲的后代智力发育迟缓的高发率有关。使用胚胎鸡模型的研究表明，乙醇暴露会抑制胎儿发育，包括抑制大脑生长。脑总环AMP含量和内源性脑蛋白激酶特异性活性不受乙醇影响；然而，乙醇暴露确实显著刺激激酶催化活性测量在外源性环AMP饱和量的存在。
Retarded fetal brain growth is associated with a high incidence of mental retardation among the offspring of chronic alcoholic mothers. Research using an embryonic chick model suggests that ethanol exposure suppresses fetal development including suppression of brain growth. Total brain cyclic AMP content and endogenous brain protein kinase specific activity are not altered by ethanol; however, ethanol exposure does significantly stimulate kinase catalytic activity measured in the presence of saturating amounts of exogenous cyclic AMP.
大鼠慢性乙醇治疗和戒断期间脑环腺苷酸水平的变化。
影响因子：
5
作者：
Shen,A;Jacobyansky,A;Pathman,D;Thurman,RG
通讯作者：
Thurman,RG