Association between hypertension and the α-adducin, β1-adrenoreceptor, and G-protein β3 subunit genes in the Japanese population;: the Suita Study
Association between hypertension and the α-adducin, β1-adrenoreceptor, and G-protein β3 subunit genes in the Japanese population;: the Suita Study
复制标题
DOI：
10.1291/hypres.27.31
复制
发表时间：
2004-01-01
影响因子：
5.4
通讯作者：
Iwai, N
中科院分区：
文献类型：
--
作者：
Shioji, K;Kokubo, Y;Iwai, N
本研究集中于3个先前与高血压有关的遗传多态性：氧化内收蛋白（ADD 1/Gly 460 Trp）、β 1肾上腺素受体（ADRB 1/Arg 389 Gly）和G蛋白83亚基（GNB 3/C825 T）基因多态性。我们使用TaqMan系统在代表日本一般人群（867名男性，1，013名女性）的大型队列中确定了遗传变异。Logistic回归分析显示，ADD 1/G460 W基因多态性与女性高血压相关。WW基因型与WG+GG基因型相比，高血压的优势比为1.53（95%CI，1.12-2.08）（p=0.0070，经Bonferroni方法校正的p校正值（pc）=0.0420）。ADRB 1/R389 G多态性与男性高血压状态相关（p= 0.0117，p（c）=0.0702）。GG基因型与RR+RG基因型相比，高血压的优势比为0.38（95%CI，0.167-0.780）。GNB 3/C825 T多态性与男性或女性受试者的高血压状态无关。目前的结果与以前的报告不一致。几乎所有常见的变异对常见疾病的影响都不大，一项研究即使有1,880名受试者参与，也可能缺乏检测出真实的关联的统计能力。因此，有必要使用来自Suita队列或其他人群的大量受试者来验证这三个基因与高血压之间的关联。
This study focused on 3 genetic polymorphisms that have previously been implicated in hypertension: the ox-adducin (ADD1/Gly460Trp), beta1-adrenoreceptor (ADRB1/Arg389Gly), and G-protein 83 subunit (GNB3/C825T) gene polymorphisms. We determined genetic variants using the TaqMan system in a large cohort representing the general population in Japan (867 males, 1,013 females). Logistic analysis indicated that the ADD1/G460W polymorphism was associated with hypertension in female subjects. The odds ratio of the WW genotype for hypertension was 1.53 (95%CI, 1.12-2.08) over the WG+GG genotype (p=0.0070, p corrected (pc) =0.0420 corrected by the Bonferroni method). The ADRB1/R389G polymorphism tended to be associated with hypertensive status in male subjects (p=0.01 17, p(c)=0.0702). The odds ratio of the GG genotype for hypertension was 0.38 (95%CI, 0.167-0.780) over the RR+RG genotype. The GNB3/C825T polymorphism was not associated with hypertensive status in either male or female subjects. The present results do not agree with those in previous reports. Almost all common variants may have only a modest effect on common diseases, and a single study even employing 1,880 subjects may lack the statistical power to detect a real association. Accordingly, it will be necessary to verify the association between these three genes and hypertension using a larger number of subjects from the Suita cohort or another population.