Smoking cessation and decreased risk of stroke in women.
Smoking cessation and decreased risk of stroke in women.
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DOI：
10.1001/jama.1993.03500020066033
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发表时间：
1993-01
期刊：
影响因子：
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通讯作者：
Ichiro Kawachi;G. Colditz;M. Stampfer;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
中科院分区：
文献类型：
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作者：
Ichiro Kawachi;G. Colditz;M. Stampfer;W. Willett;J. Manson;B. Rosner;F. Speizer;C. Hennekens
目的探讨中年妇女戒烟时间与卒中风险的关系。设计：对女性进行为期12年的随访（1976 - 1988），每2年通过邮寄问卷更新一次吸烟习惯信息。人口研究：1976年共有117,006名年龄在30至55岁之间的女性注册护士，基线时无冠心病、中风和癌症。主要结局指标：偶发性卒中（致死性和非致死性），进一步细分为缺血性卒中、蛛网膜下腔出血和脑出血。结果当前吸烟者与从不吸烟者相比，经年龄调整的总卒中相对危险度为2.58（95%可信区间2.08 ~ 3.19）。前吸烟者相应的相对危险度为1.34（95%可信区间为1.04 ~ 1.73）。对于总卒中和缺血性卒中，戒烟后2 - 4年，前吸烟者的过度风险基本消失。无论吸烟的数量、开始吸烟的年龄或是否存在其他中风风险因素，都观察到相同的下降模式。结论：戒烟后吸烟者的痛苦风险很快下降，其益处与开始吸烟的年龄和每天吸烟的数量无关。
OBJECTIVE To prospectively examine the relationship of time since stopping smoking with risk of stroke in middle-aged women. DESIGN An ongoing prospective cohort of women with 12 years' follow-up data (1976 to 1988), in which information on smoking habits was updated every 2 years by postal questionnaire. POPULATION STUDIED A total of 117,006 female registered nurses aged 30 to 55 years in 1976 and free of coronary heart disease, stroke, and cancer at baseline. MAIN OUTCOME MEASURES Incident strokes (fatal and nonfatal), further subdivided into ischemic stroke, subarachnoid hemorrhage, and cerebral hemorrhage. RESULTS The age-adjusted relative risk of total stroke among current smokers compared with never smokers was 2.58 (95% confidence interval, 2.08 to 3.19). The corresponding relative risk among former smokers was 1.34 (95% confidence interval, 1.04 to 1.73). For total and ischemic stroke, the excess risks among former smokers largely disappeared from 2 to 4 years after cessation. The same patterns of decline were observed regardless of number of cigarettes smoked, the age at starting, or the presence of other risk factors for stroke. CONCLUSIONS The risk of suffering among cigarette smokers declines soon after cessation and the benefits are independent of the age at starting and the number of cigarettes smoked per day.