Beyond conventional antibiotics - New directions for combination products to combat biofilm.
Beyond conventional antibiotics - New directions for combination products to combat biofilm.
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DOI：
10.1016/j.addr.2016.07.010
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发表时间：
2017-03
影响因子：
16.1
通讯作者：
Neff JA
中科院分区：
文献类型：
--
作者：
Bayramov DF;Neff JA
医疗器械相关感染是发病率和死亡率的重要且不断增长的来源。生物膜形成是医疗器械感染的常见特征，全身性抗生素无法有效预防或治疗。抗菌医疗器械组合产品为抗菌治疗剂的局部递送提供了一种途径，能够实现高局部浓度，同时最大限度地减少全身副作用。在这篇综述中，我们提出了考虑局部抗菌药物给药系统的设计，这可以通过在目标器械应用的背景下建模局部药代动力学来促进。除了需要局部递送之外，该领域进展的关键障碍是需要掺入有效对抗生物膜的试剂。本文旨在综述抗菌肽的关键特性，使其非常适合满足下一代抗菌医疗器械的需求，包括广谱活性，快速和杀菌作用机制，以及对生物膜的有效性。
Medical device related infections are a significant and growing source of morbidity and mortality. Biofilm formation is a common feature of medical device infections that is not effectively prevented or treated by systemic antibiotics. Antimicrobial medical device combination products provide a pathway for local delivery of antimicrobial therapeutics with the ability to achieve high local concentrations while minimizing systemic side effects. In this review, we present considerations for the design of local antimicrobial delivery systems, which can be facilitated by modeling local pharmacokinetics in the context of the target device application. In addition to the need for local delivery, a critical barrier to progress in the field is the need to incorporate agents effective against biofilm. This article aims to review key properties of antimicrobial peptides that make them well suited to meet the demands of the next generation of antimicrobial medical devices, including broad spectrum activity, rapid and biocidal mechanisms of action, and efficacy against biofilm.