Regulatory mechanisms of the bile salt export pump (BSEP/ABCB11) and its role in related diseases
Regulatory mechanisms of the bile salt export pump (BSEP/ABCB11) and its role in related diseases
复制标题
胆盐输出泵（BSEP/ABCB11）的调节机制及其在相关疾病中的作用
DOI：
10.1016/j.clinre.2021.101641
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发表时间：
2021-09-21
影响因子：
2.7
通讯作者：
Kong, Jing
中科院分区：
文献类型：
--
作者：
Ren, Tengqi;Pang, Liwei;Kong, Jing
胆盐输出泵（BSEP/ABCB 11）位于顶膜上，介导胆盐从肝细胞分泌到胆汁中。BSEP介导的胆汁盐外排是胆汁盐分泌的限速步骤，是胆汁流动的主要驱动力。BSEP驱动并维持胆盐的肠肝循环。近年来，BSEP的生理、病理功能及其调控机制的研究已成为人们关注的焦点。这些研究阐明了法尼醇X受体（FXR）、腺苷酸活化蛋白激酶（AMPK）、肝受体同源物1（LRH-1）和核因子红细胞2相关因子2（Nrf-2）在BSEP表达中的作用，并发现了一些参与BSEP转录后调控的调控因子。一系列肝脏疾病也被证明与BSEP表达和功能障碍有关，如胆汁淤积、药物诱导的肝损伤和胆结石。本文就BSEP的结构、生理功能、调控机制及相关疾病的研究进展作一综述。(c)2021 Elsevier Masson SAS。All rights reserved.
The bile salt export pump (BSEP/ABCB11) is located on the apical membrane and mediates the secretion of bile salts from hepatocytes into the bile. BSEP-mediated bile salt efflux is the rate-limiting step of bile salt secretion and the main driving force of bile flow. BSEP drives and maintains the enterohepatic circulation of bile salts. In recent years, research efforts have been focused on understanding the physiological and pathological functions and regulatory mechanisms of BSEP. These studies elucidated the roles of farnesoid X receptor (FXR), AMP-activated protein kinase (AMPK), liver receptor homolog-1(LRH-1) and nuclear factor erythroid 2-related factor 2 (Nrf-2) in BSEP expression and discovered some regulatory factors which participate in its post-transcriptional regulation. A series of liver diseases have also been shown to be related to BSEP expression and dysfunction, such as cholestasis, drug-induced liver injury, and gallstones. Here, we systematically review and summarize recent literature on BSEP structure, physiological functions, regulatory mechanisms, and related diseases. (c) 2021 Elsevier Masson SAS. All rights reserved.