Age- and sex-related characteristics in cortical thickness of femoral diaphysis for young and elderly subjects
Age- and sex-related characteristics in cortical thickness of femoral diaphysis for young and elderly subjects
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DOI：
10.1007/s00774-019-01079-9
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发表时间：
2020-01-30
影响因子：
3.3
通讯作者：
Endo, Naoto
中科院分区：
文献类型：
--
作者：
Someya, Keiichiro;Mochizuki, Tomoharu;Endo, Naoto
引言股骨干的皮质厚度被认为是评估机械使用和生物学因素的结构适应性的首选参数。本研究旨在探讨非肥胖青年人与老年人股骨干皮质厚度的年龄和性别特征。材料与方法本研究调查了34名年轻受试者（21名男性和13名女性;平均年龄：27 +/- 8岁）和52名老年受试者（29名男性和23名女性;平均年龄：70 +/- 6岁）。使用来自临床CT数据的高分辨率皮质厚度测量值，自动计算5000-8000个测量点的股骨骨干的三维（3D）皮质厚度。在12个评估区域中，通过结合股骨坐标系中的三个高度（近端、中央和远端骨干）和90度轴向平面的四个区域（内侧、前侧、外侧和后侧区域）创建，使用股骨长度评估标准化厚度。结果从趋势上看：（1）内、外侧厚度无差异，后部厚度大于前部厚度;（2）男性厚度大于女性;（3）青年厚度大于老年厚度。结论本研究结果对阐明下肢疾病的各种病理状态的原因具有临床意义。
Introduction Cortical thickness of the femoral diaphysis is assumed to be a preferred parameter in the assessment of the structural adaptation by mechanical use and biological factors. This study aimed to investigate the age- and sex-specific characteristics in cortical thickness of the femoral diaphysis between young and elderly non-obese people. Materials and methods This study investigated 34 young subjects (21 men and 13 women; mean age: 27 +/- 8 years) and 52 elderly subjects (29 men and 23 women; mean age: 70 +/- 6 years). Three-dimensional (3D) cortical thickness of the femoral diaphysis was automatically calculated for 5000-8000 measurement points using the high-resolution cortical thickness measurement from clinical CT data. In 12 assessment regions created by combining three heights (proximal, central, and distal diaphysis) and four areas of the axial plane at 90 degrees (medial, anterior, lateral, and posterior areas) in the femoral coordinate system, the standardized thickness was assessed using the femoral length. Results As per the trends, (1) there were no differences in medial and lateral thicknesses, while the posterior thickness was greater than the anterior thickness, (2) the thickness in men was higher than that in women, and (3) the thickness in young subjects was higher than that in elderly subjects. Conclusions The results of this study are of clinical relevance as reference points to clarify the causes of various pathological conditions for diseases of the lower extremities.