Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape
Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape
复制标题
DOI：
10.1007/s10753-010-9182-7
复制
发表时间：
2010-02
期刊：
影响因子：
5.1
通讯作者：
K. Yamashita;Y. Yoshioka;K. Higashisaka;Y. Morishita;Tokuyuki Yoshida;Maho Fujimura;H. Kayamuro;H. Nabeshi;T. Yamashita;K. Nagano;Y. Abe;H. Kamada;Y. Kawai;T. Mayumi;T. Yoshikawa;N. Itoh;S. Tsunoda;Y. Tsutsumi
中科院分区：
文献类型：
--
作者：
K. Yamashita;Y. Yoshioka;K. Higashisaka;Y. Morishita;Tokuyuki Yoshida;Maho Fujimura;H. Kayamuro;H. Nabeshi;T. Yamashita;K. Nagano;Y. Abe;H. Kamada;Y. Kawai;T. Mayumi;T. Yoshikawa;N. Itoh;S. Tsunoda;Y. Tsutsumi
碳纳米管(CNTs)是目前研究和开发最广泛的纳米材料之一。然而，他们的安全几乎没有受到关注。碳纳米管的生物效应被认为与大小和形状有关。因此，需要评估碳纳米管的特性与其安全性之间的关系。在这项研究中，我们检测了不同尺寸的多壁碳纳米管(MWCNTs)和单壁碳纳米管(SWCNTs)的生物学效应。长而粗的多壁碳纳米管对DNA的损伤作用最强，而相似的单壁碳纳米管对DNA的损伤作用较小。比较不同类型碳纳米管的炎症反应发现，长碳纳米管和厚碳纳米管的腹腔注射增加了小鼠腹腔灌洗液中的细胞总数。这些结果表明，长而粗的MWCNT而不是短而细的MWCNT会引起DNA损伤和严重的炎症效应。这些发现可能为构建安全的新型碳纳米管提供有用的信息。
Carbon nanotubes (CNTs) have been one of the most extensively researched and developed nanomaterials. However, little concern has been placed on their safety. The biological effects of CNTs are believed to differ relative to size and shape. Thus, the relationship between the characteristics of CNTs and their safety needs to be evaluated. In this study, we examined the biological effects of different-sized multi-walled CNTs (MWCNTs) and single-walled CNTs (SWCNTs). Long and thick MWCNTs induced the strongest DNA damage while similar SWCNTs caused little effect. Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice. These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety.