Total synthesis of biselyngbyolide A.
Total synthesis of biselyngbyolide A.
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DOI：
10.1021/ol500996n
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发表时间：
2014-12
期刊：
影响因子：
5.2
通讯作者：
Yurika Tanabe;E. Sato;Naoya Nakajima;Akifumi Ohkubo;O. Ohno;K. Suenaga
中科院分区：
文献类型：
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作者：
Yurika Tanabe;E. Sato;Naoya Nakajima;Akifumi Ohkubo;O. Ohno;K. Suenaga
BiselyngbyteA是一种18元大环内酯，对癌细胞表现出显著的生物活性，如生长抑制活性和细胞凋亡诱导活性。本研究首次实现了以分子内Stille偶联反应为关键步骤的双菱叶素A的全合成。
Biselyngbyolide A is an 18-membered macrolide that exhibits significant biological activities such as growth-inhibitory activity and apoptosis inducing activity against cancer cells. In this study, the first total synthesis of biselyngbyolide A by using an intramolecular Stille coupling reaction as a key step is achieved.