Bioaccumulation and elimination kinetics of hydroxylated polybrominated diphenyl ethers (2'-OH-BDE68 and 4-OH-BDE90) and their distribution pattern in common carp (Cyprinus carpio).
Bioaccumulation and elimination kinetics of hydroxylated polybrominated diphenyl ethers (2'-OH-BDE68 and 4-OH-BDE90) and their distribution pattern in common carp (Cyprinus carpio).
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DOI：
10.1016/j.jhazmat.2014.03.058
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发表时间：
2014-06
影响因子：
13.6
通讯作者：
Hongxia Zhao;Guolong Zhang;Sisi Liu;Baocheng Qu;Yanli Wang;D. Hu;Jingqiu Jiang;X. Quan;Jingwen Chen
中科院分区：
文献类型：
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作者：
Hongxia Zhao;Guolong Zhang;Sisi Liu;Baocheng Qu;Yanli Wang;D. Hu;Jingqiu Jiang;X. Quan;Jingwen Chen
羟基化多溴联苯醚（Hydroxylated polybrominated diphenyl ethers，OH-PBDEs）由于其毒性和在野生动物和人类体内的普遍存在而引起广泛关注。羟基-多溴二苯醚相对较高的Kow值意味着这些化合物可能具有很大的生物累积潜力，但迄今为止，现有数据提供的关于任何生物体吸收和净化动力学的信息很少。在流动系统中，将2′-OH-BDE 68和4-OH-BDE 90分别暴露于鲤鱼中30 d，然后在清水中净化60 d，以研究化合物的生物累积和组织分布。两种OH-PBDEs在鲤鱼体内均有一定的蓄积作用，且在肝脏和肾脏中的蓄积量较高。鱼类对两种OH-PBDE的吸收率（k1）范围为0.15至21.3 d-1，消除率（k2）范围为0.027至0.075 d-1，导致其BCF值在4.8-299.2范围内。半衰期范围为9.2天至25.6天。长时间暴露后，暴露浓度显著影响肝脏、肾脏和肌肉中的BCF值，但未改变其相对组成。据我们所知，这是第一项通过对照实验动物模型系统评估OH-PBDEs的吸收、净化动力学和组织分布的研究。
Hydroxylated polybrominated diphenyl ethers (OH-PBDEs) have attracted wide concerns due to their toxicities and universal presence in wildlife and humans. The relatively highKowvalues of OH-PBDEs imply these compounds may have a significant bioaccumulation potential, but so far, the existing data provide little information regarding the kinetics of uptake and depuration in any organisms. Here we exposed common carps separately to two OH-PBDEs, 2′-OH-BDE68 and 4-OH-BDE90, for 30 days (d) in a flow-through system, followed by a 60-d depuration period in clean water to investigate compound-specific bioaccumulation and tissue distribution. Two OH-PBDEs could accumulate in common carp, and the high concentration was observed in liver or kidney. The uptake rates (k1) of two OH-PBDEs ranged from 0.15 to 21.3 d−1in fish, and the elimination rates (k2) ranged from 0.027 to 0.075 d−1, which leaded to their BCF values in 4.8–299.2 ranges. Half-lives ranged from 9.2 d to 25.6 d. The exposure concentration significantly affected BCF values but didn’t change their relative compositions in liver, kidney and muscle after a long exposure time. To our knowledge, this is the first study to systematically assess uptake, depuration kinetics and tissue distribution for OH-PBDEs via a controlled experimental animal model.