Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
Risk of colorectal cancer is linked to erythrocyte compositions of fatty acids as biomarkers for dietary intakes of fish, fat, and fatty acids
复制标题
DOI：
10.1158/1055-9965.epi-06-0180
复制
发表时间：
2006-10-01
影响因子：
3.8
通讯作者：
Tajima, Kazuo
中科院分区：
文献类型：
--
作者：
Kuriki, Kiyonori;Wakai, Kenji;Tajima, Kazuo
建议食用富含n-3多不饱和脂肪酸（PUFA）的鱼类，如二十二碳六烯酸，通过抑制与肿瘤发生和细胞增殖相关的花生四烯酸（AA）级联反应来降低结直肠癌风险。饱和脂肪酸（SFA）的高摄入量可能会增加风险。为了研究结直肠癌风险与红细胞膜中脂肪酸组成之间的关系，作为鱼类，脂肪和脂肪酸饮食摄入量的生物标志物，我们对74例事件病例和221例非癌症对照进行了病例对照研究（年龄，性别和样本采集季节匹配）。红细胞脂肪酸测定采用加速溶剂萃取和气液色谱法。结直肠癌与肉类、鱼类、脂肪和脂肪酸的饮食摄入量无关。然而，该风险与二十二碳六烯酸、AA和PUFAs的红细胞成分呈负相关[最高至最低三分位数，比值比为0.36、0.42和0.15; 95%置信区间为0.14-0.93、0.18-0.95和0.05-0.46; P-trend < 0.05，respectively]，与棕榈酸、脂肪酸和脂肪酸/多不饱和脂肪酸比值呈正相关（比值比分别为6.46、8.20和9.45; 95%置信区间分别为2.41-17.26、2.86-23.52和2.84-31.43; P趋势< 0.005）。总之，我们可以清楚地表明，减少和增加相关的红细胞膜中的PUFA和SFAs组合物，分别结直肠癌的风险，但需要进一步的研究，以调查我们的研究结果和AA级联反应的普遍接受的作用之间的差异。
Consumption of fish rich in n-3 polyunsaturated fatty acids (PUFAs), such as docosahexaenoic acid, is suggested to reduce colorectal cancer risk through inhibition of the arachidonic acid (AA) cascade related to tumorigenesis and cell proliferation. High intake of saturated fatty acids (SFAs) may increase the risk. To examine associations between colorectal cancer risk and fatty acid compositions in erythrocyte membranes, as biomarkers for dietary intakes of fish, fat, and fatty acids, we conducted a case-control study with 74 incident cases and 221 noncancer controls (matched by age, sex, and season of sample collection). Erythrocyte fatty acids were measured using an accelerated solvent extraction and a gas-liquid chromatography. Colorectal cancer had no association with dietary intakes of meat, fish, fat, and fatty acids. However, the risk was inversely associated with erythrocyte compositions of docosahexaenoic acid, AA, and PUFAs [the highest to the lowest tertile, odds ratios, 0.36, 0.42, and 0.15; 95% confidence intervals, 0.14-0.93, 0.18-0.95, and 0.05-0.46; P-trend < 0.05, respectively] and positively with those of palmitic acid, SFAs, and the ratio of SFAs/PUFAs (odds ratios, 6.46, 8.20, and 9.45; 95% confidence intervals, 2.41-17.26, 2.86-23.52, and 2.84-31.43; P-trend < 0.005, respectively). In conclusion, we could clearly show decreased and increased risks for colorectal cancer related to PUFAs and SFAs compositions in erythrocyte membranes, respectively, but further research is needed to investigate the discrepancy between our findings and the generally accepted role of the AA cascade.