Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus.
Comparison of insulin-like growth factor-1 and sclerostin levels between premenopausal women with and without diabetes mellitus.
复制标题
DOI：
10.1016/j.jtumed.2021.05.007
复制
发表时间：
2021-10
影响因子：
2.2
通讯作者：
Kurniawan MR
中科院分区：
文献类型：
--
作者：
Sylvawani M;Setyohadi B;Purnamasari D;Abdullah M;Kurniawan MR
本研究评估血清胰岛素样生长因子-1（IGF-1）和硬化素水平作为绝经前2型糖尿病妇女骨形成减少的标志物。采用酶联免疫吸附法对40例绝经前糖尿病妇女血清IGF-1和sclerostin水平进行了横断面研究。分别使用Mann Whitney检验和非配对t检验比较各组之间的IGF-1和硬化蛋白水平。糖尿病组和非糖尿病组的中位IGF-1血清水平分别为40.60 ng/mL和42.7 ng/mL，无显著差异。糖尿病组中硬化蛋白的血清水平显著高于非糖尿病组（分别为132.1 pg/mL和96.0 pg/mL; p < 0.001）。绝经前糖尿病妇女硬化素水平显著高于非糖尿病组。由于sclerostin影响成骨细胞的分化和成熟，血清sclerostin可能是绝经前糖尿病妇女骨形成减少的一个标志物。
This study assesses the serum levels of insulin-like growth factor-1 (IGF-1) and sclerostin as markers of decreased bone formation in premenopausal women with type 2 diabetes mellitus. A cross-sectional study was conducted to measure serum levels of IGF-1 and sclerostin in 40 premenopausal women with and without diabetes mellitus using an enzyme-linked immunosorbent assay. The levels of IGF-1 and sclerostin were compared between the groups using the Mann Whitney test and unpaired t-test, respectively. The median IGF-1 serum levels were 40.60 ng/mL and 42.7 ng/mL in the diabetic and non-diabetic groups, respectively, with no significant difference. The serum levels of sclerostin were significantly higher in the diabetic group than in the non-diabetic group (132.1 pg/mL and 96.0 pg/mL, respectively; p < 0.001). The levels of sclerostin were significantly higher in premenopausal women with diabetes mellitus than in the non-diabetic group. Since sclerostin influences the differentiation and maturation of osteoblasts, serum sclerostin might potentially be useful as a marker of decreased bone formation in premenopausal women with diabetes.