Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions
Sorting of striatal and cortical interneurons regulated by semaphorin-neuropilin interactions
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DOI：
10.1126/science.1061891
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发表时间：
2001-08-03
期刊：
影响因子：
56.9
通讯作者：
Rubenstein, JLR
中科院分区：
文献类型：
--
作者：
Marín, O;Yaron, A;Rubenstein, JLR
大多数纹状体和皮质中间神经元来自基底端脑，随后分离到各自的靶点。在这里，我们表明，迁移皮层中间神经元避免进入纹状体，因为化学排斥信号组成的至少部分的semaphorin 3A和semaphorin 3F。迁移的中间神经元表达神经纤毛蛋白，脑信号蛋白受体，被定向到皮层;那些缺乏它们的去纹状体。神经纤毛蛋白功能的丧失增加了迁移到纹状体的中间神经元的数量。这些观察结果揭示了神经纤毛蛋白介导不同神经元群体分选到不同脑结构中的机制，并提供证据表明，除了引导轴突外，这些受体还控制中枢神经系统中的神经元迁移。
Most striatal and cortical interneurons arise from the basal telencephalon, later segregating to their respective targets. Here, we show that migrating cortical interneurons avoid entering the striatum because of a chemorepulsive signal composed at least in part of semaphorin 3A and semaphorin 3F. Migrating interneurons expressing neuropilins, receptors for semaphorins, are directed to the cortex; those lacking them go to the striatum. Loss of neuropilin function increases the number of interneurons that migrate into the striatum. These observations reveal a mechanism by which neuropilins mediate sorting of distinct neuronal populations into different brain structures, and provide evidence that, in addition to guiding axons, these receptors also control neuronal migration in the central nervous system.