Intestinal reactivity to words with emotional content and brain information processing in irritable bowel syndrome
Intestinal reactivity to words with emotional content and brain information processing in irritable bowel syndrome
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DOI：
10.1023/a:1005502119461
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发表时间：
2000-06-01
影响因子：
3.1
通讯作者：
Malt, UF
中科院分区：
文献类型：
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作者：
Blomhoff, S;Spetalen, S;Malt, UF
我们对肠道对情绪体验的反应知之甚少。因此，我们将健康对照者与非精神性肠易激综合征 (IBS) 患者以及患有恐惧性焦虑症的 IBS 患者在接触带有情感内容的日常单词时的直肠壁反应进行了比较。我们发现，70.3% 的受试者在听到愤怒词语时，直肠音调升高或降低，75.0% 的受试者在听到悲伤词语时，76.6% 的受试者在听到焦虑词语时，直肠音调升高或降低。我们还研究了大脑中相同刺激的事件相关电位。我们观察到额叶大脑对悲伤（P < 0.001）和焦虑（P = 0.013）干扰词的显着组差异，以及对愤怒（P = 0.053）干扰词的阈值显着组差异。单词系列期间直肠壁的反应显着预测了同一单词系列的额叶振幅，表明思想、大脑和肠道之间存在密切的相互作用。
The intestinal reactivity to emotional experiences is poorly understood. We therefore compared healthy controls with nonpsychiatric irritable bowel syndrome (IBS) patients and IBS patients with comorbid phobic anxiety disorders with respect to rectal wall reactivity during exposure to everyday words with emotional content. We found that 70.3% of the subjects responded either with increased or decreased rectal tone during exposure to anger words, 75.0% when exposed to sadness words, and 76.6% when exposed to anxiety words. We also investigated event-related potentials in the brain to the same stimuli. We observed significant group differences in the frontal brain to sadness (P < 0.001) and anxiety (P = 0.013) distracter words, and threshold significant group difference to anger (P = 0.053) distracter words. Rectal wall reactivity during the word series significantly predicted frontal amplitude to the same word series, indicating a close interaction among mind, brain, and gut.