MATING PHEROMONE-LIKE DIFFUSIBLE FACTOR RELEASED BY SCHIZOSACCHAROMYCES-POMBE
MATING PHEROMONE-LIKE DIFFUSIBLE FACTOR RELEASED BY SCHIZOSACCHAROMYCES-POMBE
复制标题
DOI：
10.1002/j.1460-2075.1986.tb04454.x
复制
发表时间：
1986-08-01
期刊：
影响因子：
11.4
通讯作者：
YAMAMOTO, M
中科院分区：
文献类型：
--
作者：
FUKUI, Y;KAZIRO, Y;YAMAMOTO, M
我们证明了一种扩散因子是由裂殖酵母裂殖酵母的h-细胞分泌的，裂殖酵母的交配信息素还没有被描述。这个因子，暂时命名为h −-因子，影响sh +S.pombecells，并在氮耗尽条件下诱导它们的伸长。间接证据表明它在交配过程中的生理意义。尽管它们是不育的，但h− ras 1 −细胞分泌这种因子。然而，h+ ras 1-细胞显然失去了对其反应的能力。这可能表明S的基因产物。粟酒裂殖吸虫ras癌基因的同源物pomberas 1参与对交配信息素的应答机制。
We demonstrate that a diffusible factor is secreted byh−cells of the fission yeastSchizosaccharomyces pombe, whose mating pheromones have not been described. This factor, tentatively named theh−‐factor, affectsh+S.pombecells and induces their elongation under nitrogen‐depleted conditions. Circumstantial evidence suggests its physiological significance in the mating process. Despite their sterility,h−ras1−cells secrete this factor. However,h+ras1−cells have apparently lost the ability to respond to it. This may suggest that the gene product ofS. pombe ras1, a homologue of mammalianrasoncogenes, is involved in the mechanism for responding to mating pheromones.