Recent polymorphic insertion of an Alu repeat in the baboon lipoprotein lipase (LPL) gene.
Recent polymorphic insertion of an Alu repeat in the baboon lipoprotein lipase (LPL) gene.
复制标题
最近在狒狒脂蛋白脂肪酶 (LPL) 基因中插入了 Alu 重复序列的多态性。
DOI：
10.1016/s0378-1119(97)00114-5
复制
发表时间：
1997
期刊：
影响因子：
3.5
通讯作者：
Hixson,JE
中科院分区：
文献类型：
--
作者：
Cole,SA;Birnbaum,S;Hixson,JE
We have identified a polymorphic insertion in the lipoprotein lipase (LPL) gene in a captive baboon colony. Mapping and nucleotide (nt) sequence analysis of the polymorphism showed that it is due to the presence or absence of an Alu repetitive element in intron 7 of the baboon LPL gene. This polymorphic Alu repeat has not been reported in humans, and we did not detect the repeat in a survey of the LPL intron 7 gene region in other non-human primates. Comparison of nt at diagnostic positions in this Alu insertion with different Alu subfamily consensus sequences showed that it most closely resembles the young AluY subfamily. These data suggest that this polymorphic Alu repeat inserted independently in the baboon lineage.
