Neuronal autophagy controls the axonal endoplasmic reticulum to regulate neurotransmission in healthy neurons
Neuronal autophagy controls the axonal endoplasmic reticulum to regulate neurotransmission in healthy neurons
复制标题
神经元自噬控制轴突内质网调节健康神经元的神经传递
DOI：
10.1080/15548627.2021.1893569
复制
发表时间：
--
期刊：
影响因子：
13.3
通讯作者：
Haucke V.
中科院分区：
文献类型：
--
作者：
Kuijpers M;Haucke V.
神经元是长寿的细胞，通过在称为突触的专门接触处释放神经递质进行通信。神经元健康的维持和突触功能的调节需要从突触中有效地去除受损或受损的蛋白质和细胞器。大自噬/自噬如何促进神经元和突触蛋白的周转，以及健康神经元中其主要生理底物是什么，在很大程度上是未知的。我们现在已经表明，神经元自噬的损失，通过控制轴突内质网，从而促进突触前神经传递，轴突和突触钙稳态。
Neurons are long-lived cells that communicate via release of neurotransmitter at specialized contacts termed synapses. The maintenance of neuronal health and the regulation of synaptic function requires the efficient removal of damaged or dispensable proteins and organelles from synapses. How macroautophagy/autophagy contributes to neuronal and synaptic protein turnover, and what its main physiological substrates are in healthy neurons is largely unknown. We have now shown that loss of neuronal autophagy facilitates presynaptic neurotransmission by controlling the axonal endoplasmic reticulum and, thereby, axonal and synaptic calcium homeostasis.
影响因子：
16.2
作者：
Kuijpers M;Kochlamazashvili G;Stumpf A;Puchkov D;Swaminathan A;Lucht MT;Krause E;Maritzen T;Schmitz D;Haucke V
通讯作者：
Haucke V