Functional Imaging of neuroendocrine tumors with combined PET/CT using 68Ga-DOTATATE (Dota-DPhe1,Tyr3-octreotate) and 18F-FDG
Functional Imaging of neuroendocrine tumors with combined PET/CT using 68Ga-DOTATATE (Dota-DPhe1,Tyr3-octreotate) and 18F-FDG
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DOI：
10.1002/cncr.23469
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发表时间：
2008-06-01
期刊：
影响因子：
6.2
通讯作者：
Ell, Peter Joseph
中科院分区：
文献类型：
--
作者：
Kayani, Irfan;Bomanji, Jamshed B.;Ell, Peter Joseph
背景目的是评估新的PET示踪剂Ga-68-DOTATATE在神经内分泌肿瘤（NETs）中的相关分布，并将其性能与F-18-FDG PET/CT进行比较。对38例诊断为原发性或复发性NET的连续患者的68 Ga-DOTATATE和F-18-FDG成像结果进行比较，并与基于Ki 67和有丝分裂指数的组织学肿瘤分级进行相关性分析。68 Ga-DOTATATE PET/CT的灵敏度为82%（31/38），F-18-FDG PET/CT的灵敏度为66%（25/38）。Ga-68-DOTATATE和F-18-FDG PET/CT联合诊断的敏感性为92%（35/38）。在低级别NET中，Ga-68-DOTATATE的摄取高于F-18-FDG（中位数SUV 29 vs 2.9，P
BACKGROUND. The aim was to assess the relevant distribution of the novel PET tracer Ga-68-DOTATATE in neuroendocrine tumors (NETs) with combined positron emission tomography/computed tomography (PET/CT) and compare its performance with that of F-18-FDG PET/CT.METHODS. The imaging findings with 68 Ga-DOTATATE and F-18-FDG on 38 consecutive patients with a diagnosis of primary or recurrent NET were compared and correlated with tumor grade on histology based on ki67 and mitotic index.RESULTS. The sensitivity of 68Ga-DOTATATE PET/CT was 82% (31 of 38) and that of F-18-FDG PET/CT was 66% (25 of 38). The sensitivity of combined Ga-68-DOTATATE and F-18-FDG PET/CT was 92% (35 of 38). There was greater uptake of Ga-68-DOTATATE than F-18-FDG in low-grade NET (median SUV 29 vs 2.9, P