Automated characterization of dextran/concanavalin A mixtures-A study of sensitivity and temperature dependence at low viscosity as basis for an implantable glucose sensor
Automated characterization of dextran/concanavalin A mixtures-A study of sensitivity and temperature dependence at low viscosity as basis for an implantable glucose sensor
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DOI：
10.1016/j.snb.2009.12.029
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发表时间：
2010-04-08
影响因子：
8.4
通讯作者：
Ryser, Peter
中科院分区：
文献类型：
--
作者：
Kuenzi, Simon;Meurville, Eric;Ryser, Peter
葡聚糖和刀豆球蛋白A的水溶液混合物具有潜在的血糖敏感物质的用途。我们在低粘度下研究这些混合物，这对微型机械葡萄糖传感设备特别有利。在5-290 mPas和20-40℃的范围内研究了葡萄糖依赖粘度的变化。测量在玻璃Ubbelohde粘度计中进行，与相机读出设备和两个注射泵相结合以注入葡萄糖并装载样品。该系统获得的准确度优于+/-0.6%，并允许对溶液进行全自动粘度表征。测量的灵敏度在较低的葡萄糖浓度(
Mixtures of aqueous solutions of dextran and concanavalin A have a potential use as glucose sensing substances. We investigate these mixtures at low viscosities which are especially advantageous for miniature mechanical glucose sensing devices. The glucose dependent viscosity variations were studied in the range of 5-290 mPas and 20-40 degrees C. The measurements were performed in a glass Ubbelohde viscometer, combined to a camera read-out device and two syringe pumps to inject glucose and to load the sample. The accuracy obtained with that system is better than +/- 0.6% and allows a fully automated viscosity characterization of the solution. The measured sensitivity is particularly good at lower glucose concentrations (