Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value
Impact of precontrast T10 relaxation times on dynamic contrast-enhanced MRI pharmacokinetic parameters: T10 mapping versus a fixed T10 reference value
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DOI：
10.1002/jmri.24262
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发表时间：
2014-05-01
影响因子：
4.4
通讯作者：
Merkle, Elmar M.
中科院分区：
文献类型：
--
作者：
Heye, Tobias;Boll, Daniel T.;Merkle, Elmar M.
目的研究不同对比前组织松弛 (T-10) 估计方法之间动态对比增强磁共振成像 (DCE-MRI) 药代动力学参数测量的差异：基于像素的映射与固定参考值。材料和方法在 15 项 DCE-MRI 研究中，选择女性骨盆、子宫肌瘤、左侧腰肌和第五腰椎体来代表具有不同灌注特征的组织。所有 DCE-MRI 研究均使用可变翻转角 T-10 图和 1000 毫秒的固定 T-10 参考值进行处理。五项 DCE-MRI 研究的子集均使用固定 T-10 方法进行多次处理，参考 T-10 范围为 0-2000 毫秒，增量为 100 毫秒。进行 K-trans、k(ep)、v(e) 和钆曲线下初始面积 (iAUGC) 的药代动力学测量，保持每个结构上感兴趣区域放置的位置相同。结果基于像素的 T-10 图和固定 T-10 参考值之间药代动力学输出的平均差异范围为肌肉中 k(ep) 的 6.6% 到椎体中 iAUGC 的 54.9%。在较低的 T-10 (
PurposeTo investigate variation in dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) pharmacokinetic parameter measurements between different methods of precontrast tissue relaxation (T-10) estimation: pixel-based mapping versus a fixed reference value.Materials and MethodsIn 15 DCE-MRI studies the female pelvis, uterine fibroids, the left psoas muscle, and the fifth lumbar vertebral body were chosen to represent tissues with varying perfusion characteristics. All DCE-MRI studies were processed using a variable flip angle T-10 map and a fixed T-10 reference value of 1000 msec. A subset of five DCE-MRI studies were each processed multiple times using the fixed T-10 method with the reference T-10 ranging from 0-2000 msec in 100-msec increments. Pharmacokinetic measurements of K-trans, k(ep), v(e), and initial area under the gadolinium curve (iAUGC) were performed maintaining the identical position for region of interest placement on each structure.ResultsThe mean difference in pharmacokinetic output between the pixel-based T-10 map and the fixed T-10 reference value ranged from 6.6% for k(ep) in the muscle to 54.9% for iAUGC in the vertebral body. At lower T-10 (