CD151: Basis Sequence: Mouse.
CD151: Basis Sequence: Mouse.
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CD151：基础序列：小鼠。
DOI：
10.1038/mp.a004123.01
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Zijlstra,Andries
中科院分区：
文献类型：
--
作者：
Palmer,TrenisD;Zijlstra,Andries
CD 151是跨膜蛋白的四跨膜蛋白（Tspan）家族的成员，其在哺乳动物中包括33个成员，包括CD 9（MRP 1）、CD 63（LAMP 3）、CD 81（TAPA 1）和CD 82（Kail）。该家族的所有成员都具有共同的结构，包含以紧凑的棒状方式排列的四个跨膜结构域（Hemler 2005），这导致形成大细胞外环和小细胞外环（分别为LEL和SEL）。CD 151主要作为跨膜支架蛋白发挥功能。与大多数Tspan一样，CD 151通过其LEL和短胞质尾与其他跨膜或近膜蛋白相互作用。Tspan及其伴侣蛋白的多聚化导致膜内形成大的多分子复合物。这些复合物最初被称为“四跨膜蛋白网”（Charrin et al. 2003; Kovalenko et al. 2004; Levy and Shoham 2005）;然而，最新文献将其称为四跨膜蛋白富集微域（TERM或TEM; Hemler 2008; Zöller 2009）。LEL含有对于与跨膜和膜近端配偶体的相互作用重要的大多数氨基酸，而跨膜区和胞质尾被认为是与Tspan相关的胞质信号传导分子的胞内相互作用所需的。特异性伴侣包括整合素α3β1和α6β4、磷脂酰肌醇4-激酶（PI 4激酶）和蛋白激酶C α（PKCα）。该Tspan传递生物活性的分子机制仍在研究中。CD 151参与多种正常生理过程以及病理学，包括肾功能、血管生成、血小板活化、炎症、伤口愈合、肿瘤侵袭和转移（Hemler等人，2003年; Lau等人，2004年; Koleslava等人，2004年; Cowin等人，2006年; Sachs等人，2006年; Sterk等人，2000年; Stipp和Hemler，2000年; Takeda等人，2007年; Wright等人，2004年; Yáñez-Mó等人，2008年; Zijlstra等人，2008年）。
CD151 is a member of the Tetraspanin (Tspan) family of transmembrane proteins, which encompasses 33 members in mammals, including CD9 (MRP1), CD63 (LAMP3), CD81 (TAPA1), and CD82 (Kai1). All members of this family possess a common structure containing four membrane-spanning domains arranged in a compact rod-like fashion (Hemler 2005), which leads to the formation of the large and small extracellular loops (LEL and SEL respectively). CD151 functions principally as a transmembrane scaffolding protein. Like most Tspans, CD151 interacts with other transmembrane or membrane-proximal proteins through its LEL and short cytoplasmic tails. Multimerization of the Tspan and its partner proteins leads to the formation of large multimolecular complexes within the membrane. These complexes were originally referred to as the ‘tetraspanin web’(Charrin et al. 2003; Kovalenko et al. 2004; Levy and Shoham 2005); however, the most current literature refers to them as tetraspanin-enriched microdomains (TERMs or TEM; Hemler 2008; Zöller 2009). The LEL contains the majority of amino acids important for interactions with transmembrane and membrane-proximal partners, while the transmembrane regions and cytoplasmic tails are thought to be required for intracellular interactions with Tspanassociated cytoplasmic signaling molecules. Specific partners include integrins α3β1 and α6β4, phosphatidylinositol 4-kinase (PI4 kinase) and protein kinase C α (PKCα). The molecular mechanism (s) by which this Tspan conveys biological activity remains under investigation. CD151 participates in a wide variety of normal physiological processes as well as pathologies, including kidney function, angiogenesis, platelet activation, inflammation, wound healing, tumor invasion, and metastasis (Hemler et al. 2003; Lau et al. 2004; Kolesnikova et al. 2004; Cowin et al. 2006; Sachs et al. 2006; Sterk et al. 2000; Stipp and Hemler 2000; Takeda et al. 2007; Wright et al. 2004; Yáñez-Mó et al. 2008; Zijlstra et al. 2008).