THE INTERPHOTORECEPTOR MATRIX MEDIATES PRIMATE RETINAL ADHESION
THE INTERPHOTORECEPTOR MATRIX MEDIATES PRIMATE RETINAL ADHESION
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DOI：
10.1001/archopht.1995.01100050123041
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发表时间：
1995-05-01
影响因子：
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通讯作者：
JOHNSON, LV
中科院分区：
文献类型：
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作者：
HAGEMAN, GS;MARMOR, MF;JOHNSON, LV
目的：评估视锥细胞基质鞘（视锥细胞光感受器相关的光感受器间基质的结构域，从神经视网膜延伸到视网膜色素上皮 (RPE) 表面）在视网膜粘附中的参与情况。方法：将猴和人的视网膜部分从 RPE 上剥离，通过凝集素组织化学检查组织，以确定物理分离对视锥细胞基质鞘的影响。结果：视锥细胞基质鞘与视锥细胞基质鞘牢固附着。观察到 RPE 和神经视网膜都足够坚固，足以导致 RPE 细胞片从 Bruch 膜上脱离，或者由于视网膜剥离而导致鞘撕裂。锥体基质护套在撕裂后可以显着拉伸和收缩。它们的完整性在死后第一分钟后迅速受到损害。结论：锥体基质鞘糖复合物可能通过在神经视网膜和 RPE 之间形成分子桥而在介导视网膜粘附中发挥主要作用。
Objective: To assess the participation of cone matrix sheaths, which are domains of the cone photoreceptor-associated interphotoreceptor matrix that extend from the neural retina to the surface of the retinal pigment epithelium (RPE), in retinal adhesion.Methods: Monkey and human retinas were partially peeled from the RPE, and the tissues were examined by lectin histochemistry to determine the effects of physical separation on the cone matrix sheath.Results: A firm attachment of cone matrix sheaths to both the RPE and the neural retina that was strong enough to cause detachment of sheets of RPE cells from Bruch's membrane or tearing of the sheaths as a result of retinal peeling was observed. Cone matrix sheaths can stretch considerably and contract following tearing. Their integrity was compromised rapidly after the first postmortem minute.Conclusion: Cone matrix sheath glycoconjugates are likely to play a major role in mediating retinal adhesion by forming a molecular bridge betwen the neural retina and the RPE.