Inhibition of methicillin-resistant Staphylococcus aureus colonization of oral cavities in newborns by viridans group streptococci
Inhibition of methicillin-resistant Staphylococcus aureus colonization of oral cavities in newborns by viridans group streptococci
复制标题
DOI：
10.1086/320147
复制
发表时间：
2001-05-15
影响因子：
11.8
通讯作者：
Totsuka, K
中科院分区：
文献类型：
--
作者：
Uehara, Y;Kikuchi, K;Totsuka, K
我们调查了草绿色链球菌在新生儿重症监护病房中预防耐甲氧西林金黄色葡萄球菌（MRSA）定植的作用。在一家儿童医院的26个月期间，415名新生儿中有207名（49.9%）在出院时被MRSA定殖。比较了两组住院时间匹配的新生儿未来MRSA定植的患病率：第1组（103例患者）未获得草绿色链球菌定植，第2组（63例患者）在出生时或1至2周（年龄，小于或等于11天）时获得草绿色链球菌定植。第2组患者的定植率（9.5%）显著低于第1组患者（44.7%; P <0.001）。患者特征无显著差异（例如，出生体重，疾病）。这些结果表明，草绿色组链球菌，作为细菌，以前占据口腔中的新生儿，可能会抑制以后的定植与MRSA。
We investigated the role of viridans group streptococci in the prevention of colonization with methicillin-resistant Staphylococcus aureus (MRSA) in neonatal intensive care units. During a 26-month period at a children's hospital, 207 (49.9%) of 415 newborns were colonized with MRSA by the time of discharge. Two groups of newborns with matching durations of hospitalization were compared with regard to the prevalence of future colonization with MRSA: group 1 (103 patients) did not acquire colonization with viridans group streptococci and group 2 (63 patients) did acquire colonization with viridans group streptococci at birth or by 1 to 2 weeks (age, less than or equal to 11 days). The rate of colonization among patients in group 2 (9.5%) was significantly lower than that among patients in group 1 (44.7%; P < .001). No significant difference in patient characteristics (e.g., birth weight, diseases) was observed. These results indicate that viridans group streptococci, as bacteria that formerly occupied the oral cavities in newborns, may inhibit later colonization with MRSA.