Nitric oxide in cystic fibrosis.
Nitric oxide in cystic fibrosis.
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DOI：
10.1016/j.jcf.2005.05.008
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发表时间：
2005-08-01
期刊：
影响因子：
--
通讯作者：
van der Ent, Cornelis K
中科院分区：
文献类型：
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作者：
de Winter-de Groot, Karin M;van der Ent, Cornelis K
囊性纤维化是以慢性呼吸道感染和炎症为特征的疾病，其发病率和致死率最高。呼出的一氧化氮(NO)在大多数炎症性肺部疾病中升高，在CF中降低，提示NO的形成减少、代谢增加或丢失。慢性阻塞性肺疾病呼吸道的氮氧化物代谢是复杂的，目前还不完全清楚。在本文中，我们将综述目前对NO在正常人和CF患者肺(病理)生理过程中的起源和作用的认识，对CF中NO浓度降低的可能解释和后果，以及CF患者可能的治疗策略。
Cystic fibrosis (CF) is characterized by chronic airway infection and inflammation, which accounts for most morbidity and deaths. Exhaled nitric oxide (NO), elevated in most inflammatory lung diseases, is decreased in CF, suggesting decreased formation, increased metabolism or loss of NO. The nitrogen oxide metabolism in CF airways is complex and not yet fully understood. In this article we will summarize current understanding of the origin and function of NO in (patho)physiological processes in the lung of normal subjects and CF patients, possible explanations for and consequences of reduced NO concentrations in CF and possible therapetic strategies for treatment of CF patients.