Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum
Two new bacterial DNA primase inhibitors from the plant Polygonum cuspidatum
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DOI：
10.1016/j.bmcl.2004.02.006
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发表时间：
2004-05-03
影响因子：
2.7
通讯作者：
Chan, TM
中科院分区：
文献类型：
--
作者：
Hegde, VR;Pu, HY;Chan, TM
秘鲁植物虎杖的70%甲醇水提取物。发现含有两种新的酚糖1和2，它们被鉴定为细菌DNA底物酶的抑制剂。通过高分辨核磁共振研究确定了这两个化合物的结构。化合物1和2对该酶有抑制作用，其IC50分别为4um和5um。(C)2004爱思唯尔有限公司。保留所有权利。
The 70% aqueous methanolic extract of the Peruvian plant Polygonum cuspidation sp. was found to contain two novel phenolic saccharides 1 and 2, which were identified as inhibitors of the bacterial DNA primase enzyme. Structures of these two compounds were established based on high resolution NMR studies. Compound 1 and 2 inhibited the primase enzyme with an IC50 of 4 and 5 muM, respectively. (C) 2004 Elsevier Ltd. All rights reserved.