Blood lead concentration, blood pressure, and renal function.
Blood lead concentration, blood pressure, and renal function.
复制标题
血铅浓度、血压和肾功能。
作者：
S. Pocock;A. G. Shaper;D. Ashby;T. Delves;T. Whitehead
一项针对英国24个城镇7735名中年男性的临床调查显示，血铅浓度与血压和肾功能指标有关。没有总体证据表明血铅浓度与收缩压或舒张压相关(r分别为+0.03和+0.01)。74例血铅浓度在1.8m/m ol/L(37.3微克/100m l)或以上的男性有高血压升高的迹象，但未达显著水平。血铅浓度与血肌酐浓度无相关性。血铅浓度的适度增加与平均血尿酸盐浓度的小幅增加和平均血清尿素浓度的小幅下降相关；当考虑饮酒时，这两种相关性都降低了。没有迹象表明，暴露于英国男性常见的浓度的铅会导致肾功能受损或血压升高。
Blood lead concentrations were related to blood pressure and indicators of renal function in a clinical survey of 7735 middle aged men from 24 British towns. There was no overall evidence that blood lead concentrations were associated with systolic or diastolic blood pressure (r = +0.03 and +0.01, respectively). In the 74 men with a blood lead concentration of 1.8 mumol/l (37.3 micrograms/100 ml) or more there was some suggestion of increased hypertension, but this did not reach significance. Blood lead concentration did not have any relation with serum creatinine concentration. Moderate increases in blood lead concentration were associated with small increases in mean serum urate concentration and small decreases in mean serum urea concentration; these associations were both reduced when alcohol consumption was taken into account. There is no indication that exposure to lead at concentrations commonly encountered in British men is responsible for impaired renal function or increased blood pressure.