Examining the Relations Between Children's Vagal Flexibility Across Social Stressor Tasks and Parent- and Clinician-Rated Anxiety Using Baseline Data from an Early Intervention for Inhibited Preschoolers.
Examining the Relations Between Children's Vagal Flexibility Across Social Stressor Tasks and Parent- and Clinician-Rated Anxiety Using Baseline Data from an Early Intervention for Inhibited Preschoolers.
复制标题
使用来自抑制性学龄前儿童早期干预的基线数据，检查儿童在社会压力源任务中的迷走神经灵活性与家长和临床医生评定的焦虑之间的关系。
DOI：
10.1007/s10802-023-01050-3
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发表时间：
2023
影响因子：
2.5
通讯作者：
Rubin,KennethH
中科院分区：
文献类型：
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作者：
Wagner,NicholasJ;Shakiba,Nila;Bui,HongNT;Sem,Kathy;Novick,DanielleR;Danko,ChristinaM;Dougherty,LeaR;Chronis-Tuscano,Andrea;Rubin,KennethH
早期行为抑制（BI）是后来焦虑症的已知危险因素。儿童副交感神经系统 (PNS) 功能的变异性可能有助于了解高 BI 儿童焦虑结果的显着异质性。然而，由于过度依赖静态功能测量，差距仍然存在，这限制了我们利用 PNS 功能来识别焦虑风险的能力。我们使用对受抑制的学龄前儿童的早期干预研究的基线数据来解决这些差距，通过描述迷走神经灵活性（VF）（PNS 功能非线性变化的指数），跨社会压力源任务，并检查 VF 与焦虑之间的关联。根据 BI 选择了 151 名家长及其 3.5 至 5 岁的孩子参加早期干预计划（ClinicalTrials.gov 注册号：NCT02308826）。结构方程模型框架被用来模拟儿童在各种任务中的心颤，这些任务旨在模拟接触新的社交互动，并测试心颤和焦虑之间的预测联系。表现出较少 VF 的儿童，其特点是抑制较少且恢复较平坦，被父母和临床医生认为更焦虑。此外，多组模型表明，符合社交焦虑症诊断标准的儿童在社交压力源任务中表现出明显较少的 VF。在性格内向的青少年中，心室颤动减少是焦虑的一个危险因素，可能反映出个人积极应对外部需求的能力下降。研究结果有助于我们了解幼儿期焦虑风险的调节过程。
Early behavioral inhibition (BI) is a known risk factor for later anxiety disorder. Variability in children’s parasympathetic nervous system (PNS) functioning may provide insight into the substantial heterogeneity in anxiety outcomes for children high in BI. However, gaps persist due to an over-reliance on static measures of functioning, which limits our ability to leverage PNS functioning to identify risk for anxiety. We address these gaps using baseline data from an early intervention study of inhibited preschoolers by characterizing vagal flexibility (VF), an index of non-linear change in PNS functioning, across social stressor tasks and by examining the associations between VF and anxiety. One hundred and fifty-one parents and their 3.5- to 5-year-old children were selected on the basis of BI to participate in an early intervention program (ClinicalTrials.gov registration: NCT02308826). A structural equation modeling framework was used to model children’s VF across tasks designed to mimic exposure to novel social interactions and to test the predictive links between VF and anxiety. Children who showed less VF, characterized by less suppression and flatter recovery, were rated by both parents and clinicians as more anxious. Moreover, a multiple group model showed that children meeting diagnostic criteria for social anxiety disorder demonstrated significantly less VF across social stressor tasks. Among inhibited youth, reduced VF is a risk factor for anxiety and may reflect an individual’s reduced capacity to actively cope with external demands. Study results contribute to our understanding of the regulatory processes underlying risk for anxiety in early childhood.