Magnetic fields increase cell survival by inhibiting apoptosis via modulation of Ca2+ influx
Magnetic fields increase cell survival by inhibiting apoptosis via modulation of Ca2+ influx
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DOI：
10.1096/fasebj.13.1.95
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发表时间：
1999-01-01
期刊：
影响因子：
4.8
通讯作者：
Ghibelli, L
中科院分区：
文献类型：
--
作者：
Fanelli, C;Coppola, S;Ghibelli, L
研究发现，强度从 6 高斯 (6X10(-4) 特斯拉，T) 开始的静态磁场会以强度依赖性方式降低，在 6 X 10(-3) T 处达到稳定水平，这是不同人类细胞系统中几种药剂诱导的细胞凋亡导致的细胞死亡程度。这并不是由于细胞死亡模式的改变（即坏死）或过程本身的延迟；而是由于细胞死亡的方式发生了变化。相反，磁场的存在允许被凋亡剂击中的细胞无限期地存活和复制。研究发现，这种保护作用是由电场增强细胞外介质 Ca2+ 流入的能力介导的。因此，它仅限于那些 Ca2+ 流入被证明具有抗凋亡作用的细胞系统。因此，磁场可能会通过改变/恢复细胞死亡和增殖之间的平衡来干扰人类健康；事实上，受损细胞的拯救可能是解释为什么本身不具有诱变性的磁场通常能够增加突变和肿瘤频率的机制。
Static magnetic fields with intensities starting from 6 gauss (6X10(-4) tesla, T) were found to decrease in an intensity-dependent fashion, reaching a plateau at 6 X 10(-3) T, the extent of cell death by apoptosis induced by several agents in different human cell systems. This is not due to a change in the mode of cell death (i,e., to necrosis) or to a delay of the process itself; rather, the presence of magnetic fields allows the indefinite survival and replication of the cells hit by apoptogenic agents. The protective effect was found to be mediated by the ability of the fields to enhance Ca2+ influx from the extracellular medium; accordingly, it was limited to those cell systems where Ca2+ influx was shown to have an antiapoptotic effect. Magnetic fields thus might interfere with human health by altering/restoring the equilibrium between cell death and proliferation; indeed, the rescue of damaged cells may be the mechanism explaining why magnetic fields that are not mutagenic per se are often able to increase mutation and tumor frequencies.,