Comparison of peripheral and central biopsy sites for the isolation of Borrelia burgdorferi sensu lato from erythema migrans skin lesions.
Comparison of peripheral and central biopsy sites for the isolation of Borrelia burgdorferi sensu lato from erythema migrans skin lesions.
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从游走性红斑皮肤病变中分离伯氏疏螺旋体的外周和中心活检部位的比较。
DOI：
10.1086/514715
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发表时间：
1998
期刊：
影响因子：
--
通讯作者：
Strle,F
中科院分区：
文献类型：
--
作者：
Jurca,T;Ruzić-Sabljić,E;Lotric-Furlan,S;Maraspin,V;Cimperman,J;Picken,RN;Strle,F
为了比较外周和中央活检部位从典型的游走性红斑病变中分离出伯氏疏螺旋体，从53例成人患者中各取两份活检标本（一份来自病变边缘，另一份来自病变中心）。106例活检标本中有34例（32.1%）和53例患者中有23例（43.4%）培养阳性。在53例中央活检中的19例（35.9%）和53例外周活检中的15例（28.3%）中分离出螺旋体（无显著差异）。8例仅中央型标本阳性，4例仅外周型标本阳性，11例两种标本均阳性。在36个环形和17个均匀病变的比较中，从前者的15个（41.7%）和后者的8个（47.1%）中分离出疏螺旋体。在环状病变活检中，11例中央和12例外周标本培养阳性。在恶性病变活检中，8个中央和3个外周标本培养阳性（无显著差异）;仅在均质病变的边缘没有培养阳性结果。本研究表明，B.从游走性红斑病变的中心方面可以与从外周方面一样有效地分离出大伯氏症。
To compare peripheral and central biopsy sites for the isolation ofBorrelia burgdorferisensu lato from typical erythema migrans lesions, two biopsy specimens (one from the margin and the other from the center of the lesion) were taken from each of 53 adult patients. Thirty-four (32.1%) of the 106 biopsy specimens and 23 (43.4%) of the 53 patients were culture-positive. Spirochetes were isolated in 19 (35.9%) of the 53 central and 15 (28.3%) of the 53 peripheral biopsies (nonsignificant difference). In 8 cases only the central specimen, in 4 cases only the peripheral specimen, and in 11 cases both specimens were positive. In a comparison of 36 annular and 17 homogeneous lesions, borreliae were isolated from 15 (41.7%) of the former and 8 (47.1%) of the latter. In the annular-lesion biopsies, 11 central and 12 peripheral specimens were culture-positive. In the homogeneous-lesion biopsies, eight central and three peripheral specimens were culture-positive (nonsignificant difference); there were no culture-positive results solely for the margin of homogeneous lesions. This study demonstrates thatB. burgdorferisensu lato may be isolated from the central aspect of erythema migrans lesions as efficiently as from the peripheral aspect.