Ethanol-induced changes in body sway in men at high alcoholism risk.
Ethanol-induced changes in body sway in men at high alcoholism risk.
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乙醇引起的酒精中毒风险高的男性身体摇摆变化。
DOI：
10.1001/archpsyc.1985.01790270065007
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发表时间：
1985
影响因子：
--
通讯作者：
M. Schuckit
中科院分区：
文献类型：
--
作者：
M. Schuckit
这项研究测量了34名21至25岁有酗酒一级亲属（家族史阳性组，或FHP组）的饮酒但不饮酒的男性的身体摇摆或静态共济失调的量。结果与34名对照受试者进行比较，这些受试者在人口统计学特征和饮酒史上两两匹配，但没有已知的酗酒近亲（家族史阴性组，或FHN组）。每个人在三种情况下接受测试，他们要么喝安慰剂，要么喝0.75 mL/kg或1.1 mL/kg的乙醇；在接下来的四个小时里，研究对象被反复测试。在三个测试阶段的每一个基线上，两组有家族病史的人的身体摇摆水平几乎是相同的。然而，在0.75 mL/kg的剂量下，FHP组的身体摇摆的增加明显小于FHN组，在摄入1.1 mL/kg的乙醇后，发现了相似但不那么明显的组差异。这些结果与FHP男性在饮酒后明显不那么强烈的主观陶醉感相一致，也与生物和认知测试分数中不那么强烈的酒精相关变化的发现相一致。对乙醇反应强度的降低应进一步作为酒精中毒易感性的可能遗传特征标记加以探讨。
This study measures the amount of body sway or static ataxia in 34 drinking but nonalcoholic men 21 to 25 years of age who have an alcoholic first-degree relative (the family-history-positive, or FHP, group). Results are compared with 34 control subjects matched pairwise on demographic characteristics and drinking histories, but who have no known alcoholic close relatives (the family-history-negative, or FHN, group). Each man was tested on three occasions where he drank either placebo, or 0.75 mL/kg or 1.1 mL/kg of ethanol; the subjects were repeatedly tested during the subsequent four hours. At the baseline of each of the three test sessions, the level of body sway for the two family-history groups was virtually identical. However, following the 0.75-mL/kg dose, the increase in body sway was significantly less for the FHP than for FHN group, with similar but less dramatic group differences noted following the ingestion of 1.1 mL/kg of ethanol. These results are consistent with the significantly less intense subjective feelings of intoxication after drinking for the FHP men, and also parallel findings of less intense ethanol-related changes in biologic and cognitive test scores. A decreased intensity of reaction to ethanol should be explored further as a possible genetic trait marker of a predisposition toward alcoholism.
酗酒者和对照组的亲属摄入乙醇后血浆皮质醇的差异：初步结果。
DOI：
--
发表时间：
1984
期刊：
The Journal of clinical psychiatry
影响因子：
--
作者：
Schuckit,MA
通讯作者：
Schuckit,MA
乙醇相关的催乳素反应和酒精中毒的风险。
影响因子：
10.6
作者：
Schuckit,MA;Parker,DC;Rossman,LR
通讯作者：
Rossman,LR
影响因子：
--
作者：
Cloninger,CR;Bohman,M;Sigvardsson,S
通讯作者：
Sigvardsson,S