Parameter sensitivity analysis of a network model of systemic circulatory mechanics
Parameter sensitivity analysis of a network model of systemic circulatory mechanics
复制标题
全身循环力学网络模型的参数敏感性分析
DOI：
10.1007/bf02368499
复制
发表时间：
1974
影响因子：
3.8
通讯作者：
F. Grodins
中科院分区：
文献类型：
--
作者：
Toshiro Sato;S. Yamashiro;D. Vega;F. Grodins
先前的系统循环系统分析模型（Grodins,Quarterly Review of Biology, 1959, 34,93 - 116）基于最近的实验研究得到了扩展。考虑的主要单位是：大动脉、大静脉和外周循环。后者被细分为三个平行的功能单元：(1)营养床，(2)分流通路和(3)储存区。通过对心肺循环的简化线性描述，考虑了整个心血管系统。参数值主要来源于右心旁路（Grodins, Stuart, and Veenstra, American Journal Physiology, 1960198,552 - 560）和分离后肢（Satoet al., 1971）实验。导出了心输出量与全身循环参数之间的代数方程，为研究参数变化的影响提供了一种方便的方法。该方程预测顺应性和无应力体积对心输出量有单向影响，但动脉阻力有可变影响，这取决于平行通路的阻力和顺应性的值。根据频率响应法获得的实验值，通过改变营养床的顺应性和阻力来考虑运动的循环反应（Vega, Ph.D. Thesis, University of Southern California, 1973）。讨论了阻力变化所要求的血流恢复的可能机制。综上所述，系统循环力学似乎主要通过不同节段之间的血容量再分配而不是血流再分配来影响心输出量。
A previous analytical model of the systemic circulatory system (Grodins,Quarterly Review of Biology, 1959,34, 93–116) was extended based on recent experimental studies. Major units considered are: large arteries, large veins, and the peripheral circulation. The latter is subdivided into three parallel functional units: (1) nutritional bed, (2) shunt pathway and (3) storage area. By addition of simplified linear descriptions for the heart and pulmonary circulation, the overall cardiovascular system was considered. Parameter values were mainly derived from right heart bypass (Grodins, Stuart, and Veenstra, American Journal of Physiology, 1960198, 552–560) and isolated hindlimb (Satoet al., 1971) experiments. An algebraic equation relating cardiac output to systemic circulatory parameters was derived which provided a convenient means of studying effects of parameter changes. This equation predicted that compliances and unstressed volumes have a unidirectional effect on cardiac output but arterial resistance has a variable effect which depends on the values of resistances and compliances of the parallel pathways. Circulatory responses to exercise were considered by changing compliance and resistance of the nutritional bed in accordance with experimental values obtained with a frequency response method (Vega, Ph.D. Thesis, University of Southern California, 1973). Possible mechanisms for blood flow restoration as required by the resistance change are discussed.In summary, systemic circulatory mechanics appear to influence cardiac output mainly by redistribution of blood volume between different segments rather than by redistribution of blood flow.