Optimism and Psychological Resilience are Beneficially Associated With Measures of Clinical and Experimental Pain in Adults With or at Risk for Knee Osteoarthritis.
Optimism and Psychological Resilience are Beneficially Associated With Measures of Clinical and Experimental Pain in Adults With or at Risk for Knee Osteoarthritis.
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乐观和心理弹性与患有膝骨关节炎或有膝骨关节炎风险的成人的临床和实验性疼痛测量有益相关。
DOI：
10.1097/ajp.0000000000000642
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Go
中科院分区：
文献类型：
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作者：
Thompson,KathrynA;Bulls,HaileyW;Sibille,KimberlyT;Bartley,EmilyJ;Glover,ToniL;Terry,EllenL;Vaughn,IvanaA;Cardoso,JosueS;Sotolongo,Adriana;Staud,Roland;Hughes,LauraB;Edberg,JeffreyC;Redden,DavidT;Bradley,LaurenceA;Go
目的：这项横断面研究考察了乐观、心理韧性、内源性疼痛抑制和临床膝关节疼痛严重程度之间的关系。对两个假设进行了检验。首先，我们假设实验测试的内源性疼痛抑制将在乐观情绪和临床膝关节疼痛严重程度之间起中介作用。其次，还假设乐观情绪会调节心理弹性与内源性疼痛抑制和临床膝关节疼痛严重程度的关系。方法：对150名有症状性膝骨性关节炎或有症状膝骨性关节炎风险的个体，分别采用修订的生活定向测验、简明弹性量表和修订的简明麦吉尔疼痛问卷-2评估乐观情绪、心理弹性和临床膝关节疼痛严重程度。采用疼痛测量(测试刺激)的条件性疼痛调制(CPM)方案和冷加压任务(条件性刺激)对内源性疼痛抑制进行了实验研究。结果：根据假设，CPM的增加显著地中介了更高的乐观性和更低的临床膝关节疼痛严重程度之间的关联。此外，乐观情绪缓和了心理韧性和CPM之间的联系。然而，与我们的假设相反，只有在乐观程度较低的个体中，更强的心理韧性与更高的CPM相关。讨论：
Objectives:This cross-sectional study examined the associations among optimism, psychological resilience, endogenous pain inhibition, and clinical knee pain severity. Two hypotheses were tested. First, we hypothesized that experimentally tested endogenous pain inhibition would mediate the relationship between optimism and clinical knee pain severity. Second, it was also hypothesized that optimism would moderate the relationships of psychological resilience with endogenous pain inhibition and clinical knee pain severity, particularly for individuals with high optimism.Methods:A total of 150 individuals with or at risk for symptomatic knee osteoarthritis completed the Life Orientation Test-Revised, the Brief Resilience Scale, and the revised Short-Form McGill Pain Questionnaire-2 to assess optimism, psychological resilience, and clinical knee pain severity, respectively. Endogenous pain inhibition was examined experimentally using a conditioned pain modulation (CPM) protocol with algometry (test stimulus) and a cold pressor task (conditioning stimulus).Results:As hypothesized, results showed that increased CPM significantly mediated the association between higher optimism and lower clinical knee pain severity. Further, optimism moderated the association between psychological resilience and CPM. However, contrary to our hypothesis, greater psychological resilience was associated with enhanced CPM in individuals with low optimism only.Discussion: