Prevalence and clinical outcome of mitral-valve prolapse
Prevalence and clinical outcome of mitral-valve prolapse
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DOI：
10.1056/nejm199907013410101
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发表时间：
1999-07-01
影响因子：
158.5
通讯作者：
Benjamin, EJ
中科院分区：
文献类型：
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作者：
Freed, LA;Levy, D;Benjamin, EJ
背景：二尖瓣脱垂是一种常见的并发症。为了确定二尖瓣脱垂在普通人群中的患病率，使用当前的二维超声心动图标准进行诊断，我们检查了参加Framingham心脏研究后代队列第五次检查的1845名女性和1646名男性（平均[+/-SD]年龄，54.7+/-10.0岁）的超声心动图。方法将二尖瓣脱垂定义为收缩期二尖瓣上部脱垂大于2mm，分离期二尖瓣最大厚度不小于5mm；将二尖瓣脱垂定义为位移大于2mm，最大厚度小于5mm。结果84例（2.4%）二尖瓣脱垂，47例（1.3%）二尖瓣脱垂，37例（1.1%）二尖瓣脱垂。他们的年龄和性别分布与没有脱垂的受试者相似。有脱垂的受试者均无心力衰竭史，1人（1.2%）有心房颤动，1人（1.2%）有脑血管疾病，3人（3.6%）有晕厥，与未调整的无脱垂受试者相比，这些发现的患病率分别为0.7、1.7、1.5和3.0%。胸痛、呼吸困难和心电图异常的频率在有脱垂和没有脱垂的受试者中相似。脱垂者较瘦弱(P
Background Mitral-valve prolapse has been described as a common disease with frequent complications. To determine the prevalence of mitral-valve prolapse in the general population, as diagnosed with the use of current two-dimensional echocardiographic criteria, we examined the echocardiograms of 1845 women and 1646 men (mean [+/-SD] age, 54.7+/-10.0 years) who participated in the fifth examination of the offspring cohort of the Framingham Heart Study.Methods Classic mitral-valve prolapse was defined as superior displacement of the mitral leaf lets of more than 2 mm during systole and as a maximal leaflet thickness of at least 5 mm during diastasis, and nonclassic prolapse was defined as displacement of more than 2 mm, with a maximal thickness of less than 5 mm.Results A total of 84 subjects (2.4 percent) had mitral-valve prolapse: 47 (1.3 percent) had classic prolapse, and 37 (1.1 percent) had nonclassic prolapse. Their age and sex distributions were similar to those of the subjects without prolapse. None of the subjects with prolapse had a history of heart failure, one (1.2 percent) had atrial fibrillation, one (1.2 percent) had cerebrovascular disease, and three (3.6 percent) had syncope, as compared with unadjusted prevalences of these findings in the subjects without prolapse of 0.7, 1.7, 1.5, and 3.0 percent, respectively. The frequencies of chest pain, dyspnea, and electrocardiographic abnormalities were similar among subjects with prolapse and those without prolapse. The subjects with prolapse were leaner (P