Computationally Assisted Engineering of Protein Cages

Computationally Assisted Engineering of Protein Cages
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DOI:
10.1007/978-1-4939-2131-7_5
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发表时间:
2015-01-01
期刊:
PROTEIN CAGES: METHODS AND PROTOCOLS
影响因子:
--
通讯作者:
Orner, Brendan P.
Orner, Brendan P.
中科院分区:
其他
文献类型:
--
作者:
Ardejani, Maziar S.;Orner, Brendan P.

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描述了一种混合计算方法,结合了蛋白质表面的地形分析和蛋白质纳米笼中蛋白质-蛋白质相互作用的自由能计算。这种设计策略可用于工程蛋白笼,以增强结构稳定性和组装。
A hybrid computational method incorporating topographic analysis of protein surfaces and free-energy calculations of protein-protein interactions in protein nanocages is described. This design strategy can be used to engineer protein cages for enhanced structural stability and assembly.