Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
Glycolysis in the african trypanosome: targeting enzymes and their subcellular compartments for therapeutic development.
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DOI：
10.4061/2011/123702
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Morris JC
中科院分区：
文献类型：
--
作者：
Coley AF;Dodson HC;Morris MT;Morris JC
非洲锥虫（布氏锥虫）的亚种会导致非洲人类锥虫病，它们由采采蝇传播，在昆虫媒介和人类宿主中都存在对传播至关重要的生命周期阶段。在感染人类宿主期间，寄生虫仅限于利用宿主糖类的糖酵解来产生三磷酸腺苷（ATP）。这种对葡萄糖分解的依赖为潜在的治疗开发提供了一系列靶点，其中许多已通过实验被探索并确认为治疗靶点。这些靶点包括直接参与葡萄糖代谢的酶（例如锥虫己糖激酶），以及发育和维持容纳该途径主要部分的必需亚细胞区室（糖质体）所需的细胞成分。
Subspecies of the African trypanosome, Trypanosoma brucei, which cause human African trypanosomiasis, are transmitted by the tsetse fly, with transmission-essential lifecycle stages occurring in both the insect vector and human host. During infection of the human host, the parasite is limited to using glycolysis of host sugar for ATP production. This dependence on glucose breakdown presents a series of targets for potential therapeutic development, many of which have been explored and validated as therapeutic targets experimentally. These include enzymes directly involved in glucose metabolism (e.g., the trypanosome hexokinases), as well as cellular components required for development and maintenance of the essential subcellular compartments that house the major part of the pathway, the glycosomes.