Infection, immunity, and hormones/endocrine interactions
Infection, immunity, and hormones/endocrine interactions
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DOI：
10.1016/j.idc.2007.06.002
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发表时间：
2007-09-01
影响因子：
4.4
通讯作者：
Khardori, Nancy
中科院分区：
文献类型：
--
作者：
Khardori, Romesh;Adamski, Alys;Khardori, Nancy
感染和压力，免疫反应和激素是相互关联的，确保免疫能力来应对压倒性感染和代谢崩溃的直接威胁。细胞因子作为关键信号介质的出现和对激素自分泌-旁分泌影响的认识有助于解释信号是如何传递和引起反应的。这导致了创造疗法的可能性，这些疗法可用于增强保护信号并抑制从宿主和入侵生物体相互作用中发出的信号，否则这些信号可能是有害的。纠正某些代谢异常，如高血糖症和代谢性酸中毒，通过降低发病率和死亡率使宿主受益。
Infections and stress, immune responses, and hormones are interconnected, ensuring immune competence to deal with immediate threat of overwhelming infection and metabolic collapse. Emergence of cytokines as key signal mediators and appreciation of autocrine-paracrine influences of hormones have helped explain how signals are transmitted and responses evoked. This has led to possibilities of creating therapies that might be used to enhance protective signals and dampen signals emanating from host and invading organism interaction that might otherwise be detrimental. Correcting certain metabolic abnormalities, such as hyperglycemia and metabolic acidosis, benefits the host by decreasing morbidity and mortality.