A POPULATION-BASED EVALUATION OF GLAUCOMA SCREENING - THE BALTIMORE EYE SURVEY
A POPULATION-BASED EVALUATION OF GLAUCOMA SCREENING - THE BALTIMORE EYE SURVEY
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DOI：
10.1093/oxfordjournals.aje.a116013
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发表时间：
1991-11-15
影响因子：
5
通讯作者：
SOMMER, A
中科院分区：
文献类型：
--
作者：
TIELSCH, JM;KATZ, J;SOMMER, A
巴尔的摩眼睛调查是1985年1月至1988年11月在马里兰州巴尔的摩东部40岁或以上的居民中进行的一项基于人口的调查。共有5308名黑人受试者和5308名白人受试者接受了青光眼的全面筛查检查，包括眼压、视野、立体眼底摄影以及详细的医疗和眼科病史。根据明确的检查，196人被诊断为任何类型的青光眼。眼压计、杯盘比和最窄的神经视网膜边缘宽度被评估为它们正确地将受试者划分为疾病或非疾病状态的能力。无论是单独还是联合，这些变量都没有提供灵敏度和特异度的合理平衡的分界值。Logistic回归模型适用于人口统计学和其他危险因素。计算了不同截断水平下预测概率分布的灵敏度和特异度。没有获得合理敏感性和特异性的临界值。作者得出结论，目前青光眼筛查技术的有效性是有限的。
The Baltimore Eye Survey was a population-based survey conducted from January 1985 to November 1988 among residents of east Baltimore, Maryland, who were 40 years of age or older. A total of 5,308 black subjects and white subjects received a comprehensive screening examination for glaucoma including tonometry, visual fields, stereoscopic fundus photography, and a detailed medical and ophthalmic history. Based on a definitive examination, a diagnosis of glaucoma of any type was made for 196 persons. Tonometry, cup:disc ratio, and narrowest neuroretinal rim width were evaluated for their ability to correctly classify subjects into diseased or nondiseased states. There were no cutoff values at which these variables provided a reasonable balance of sensitivity and specificity, separately or in combination. Logistic regression models were fit that included demographic and other risk factors. Sensitivities and specificities were calculated for varying cutoff levels on the distribution of predicted probabilities. There was no cutoff for which reasonable sensitivity and specificity were obtained. The authors conclude that the effectiveness of current techniques for glaucoma screening is limited.