Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats
Two-kidney, two clip renovascular hypertensive rats can be used as stroke-prone rats
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DOI：
10.1161/01.str.29.8.1708
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发表时间：
1998-08-01
期刊：
影响因子：
8.3
通讯作者：
Huang, RX
中科院分区：
文献类型：
--
作者：
Zeng, JS;Zhang, YQ;Huang, RX
背景和目的：易卒中的自发性高血压大鼠的脑血管病变不仅依赖于高血压，而且部分与压力非依赖性遗传因素有关。本研究的目的是观察是否自发性中风发生在肾血管性高血压大鼠没有遗传deficiency. Methods的1-kidney，1个剪辑（1 k1 c）; 2-kidney，1个剪辑（2k 1c）;和2-kidney，2个剪辑（2k 2c）的方法被用来诱导高血压的雄性Sprague-Dawley大鼠与环形银夹。假手术大鼠作为对照。在无任何人工诱导的情况下，观察大鼠的血压和神经症状。结果2k 2c组稳定期高血压的发病率为100%（55/55），显著高于1 k1 c组（23/30，76.7%）和2k 1c组（21/30，70%）（P
Background and Purpose-The cerebrovascular lesions in stroke-prone spontaneously hypertensive rats are not only dependent on high blood pressure but partly related to pressure-independent genetic factors. The aim of the present study was to observe whether spontaneous stroke occurred in renovascular hypertensive rats without a genetic deficiency.Methods-The 1-kidney, 1 clip (1k1c); 2-kidney, 1 clip (2k1c); and 2-kidney, 2 clip (2k2c) methods were used to induce hypertension in male Sprague-Dawley rats with a ring-shaped silver clip. Sham-operated rats were used as controls. Blood pressure and neurological symptoms were observed in the rats without any artificial inducement. Brain sections stained with hematoxylin-eosin and phosphotungstic acid-hematoxylin were examined under a microscope to determine stroke foci.Results-The attack rate of stable hypertension was 100% (55/55) in the 2k2c group, which was significantly higher than that in the 1k1c (23/30, 76.7%) and 2k1c (21/30, 70%) groups (P