THE INFLUENCE OF EXPERIMENTAL ALCOHOL LOAD AND ALCOHOL INTOXICATION ON S100B CONCENTRATIONS

THE INFLUENCE OF EXPERIMENTAL ALCOHOL LOAD AND ALCOHOL INTOXICATION ON S100B CONCENTRATIONS
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DOI：
10.1097/shk.0b013e31822bd07d
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发表时间：
2011-10-01
期刊：
SHOCK
影响因子：
3.1
通讯作者：
Ambrosch, Andreas
Ambrosch, Andreas
中科院分区：
医学2区
文献类型：
--
作者：
Brin, Thomas;Borucki, Katrin;Ambrosch, Andreas

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由于近50%的轻度头部创伤患者是酒精中毒，神经功能障碍通常仍不清楚是由于酒精中毒还是脑内损伤。为了避免在轻度头部创伤患者中进行不必要的头部CT检查，S100B目前被用作细胞脑损伤的排除标记。然而，S100B水平是否受到酒精本身的影响仍不清楚。因此，我们对无创伤的酒精中毒患者进行了一项病例对照研究，以证明血清S100B是否因酒精摄入而改变。此外，我们还调查了酒精输注结合初始口服酒精负荷达到血液酒精稳定状态100 mg/dL是否会影响健康志愿者(n=12)的S100B水平。在此标准化实验程序中，未发现S100B水平显著升高。与正常对照组(n=60)相比，酒精中毒组(n=61，平均酒精浓度251mgdL)的S100B水平明显升高(0.193[SD，0.45vs.0.063[SD，0.059]mU/L；P&lt；0.001)，其中39%的患者S100B水平高于病理临界值(>0.104 mU/L)，但无明显相关性。我们的临床数据表明，血液酒精浓度远远超过100 mg/dL与酒精中毒患者S100B水平的升高有关。
Because nearly 50% of patients with mild head trauma are alcohol intoxicated, it often remains unclear if the neurological deficits are due to alcohol intoxication or to intracerebral damage. To avoid unnecessary head computed tomography investigations in patients with mild head trauma, S100B is currently used as an exclusion marker for cellular brain damage. However, whether S100B levels are influenced by alcohol itself remains to be unclear. Therefore, we performed a case-control study of nontraumatized, alcohol-intoxicated patients to prove if serum S100B is altered by alcohol uptake. Furthermore, we investigated if alcohol infusions combined with an initial oral alcohol load up to a blood alcohol steady state of 100 mg/dL affected S100B levels in healthy volunteers (n = 12). In this standardized experimental procedure, no significant increase in S100B levels could be found. In contrast, compared with the control group (n = 60 sober and healthy), the ethyl alcohol-intoxicated patients (n = 61; mean ethyl alcohol, 251 [SD, 87] mg/dL) had higher S100B concentrations (0.193 [SD, 0.45] vs. 0.063 [SD, 0.059] mu g/L; P < 0.001), and 39% of them had levels greater than the pathologic cutoff at greater than 0.104 mu g/L. However, no significant correlation was found between ethyl alcohol concentrations and S100B within the respective group. Our clinical data suggest that blood alcohol concentrations far in excess of 100 mg/dL are associated with increased S100B levels in alcohol-intoxicated patients.