Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington disease
Motor-cognitive dual-task deficits in individuals with early-mid stage Huntington disease
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DOI：
10.1016/j.gaitpost.2016.07.014
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发表时间：
2016-09-01
期刊：
影响因子：
2.4
通讯作者：
Quinn, Lori
中科院分区：
文献类型：
--
作者：
Fritz, Nora E.;Hamana, Katy;Quinn, Lori
背景资料：亨廷顿病（HD）导致一系列认知和运动障碍，并在疾病的各个阶段不断发展;然而，很少有研究评估这一人群的特定双重任务能力，以及它们与功能能力的相关程度。目的：本研究的目的是a）检查HD个体的简单和复杂运动认知双任务表现，B）确定双任务行走能力和疾病特异性运动，认知和功能能力的措施之间的关系，和c）检查双任务措施的关系，以福尔斯在个人HD.Methods：32个人HD进行了简单和复杂的双任务能力进行了评估，使用边走边说测试。人口统计学和疾病的具体措施的运动，认知和功能ability.Results：HD的个人有障碍，在简单和复杂的双重任务的能力。简单的双任务步行与疾病特异性运动评分以及认知表现相关，但复杂的双任务步行与总功能能力以及一系列认知测量相关。前瞻性的福尔斯的数量是中度强相关的双任务measurements.Conclusions：我们的研究结果表明，HD的个人有认知运动双任务能力的损害，与疾病进展和具体的功能能力。双任务测量似乎评价了早期至中期HD个体的独特结构，并可能在改善该人群中福尔斯风险的预测方面具有价值。(C)© 2016 Elsevier B. V.版权所有。
Background: Huntington disease (HD) results in a range of cognitive and motor impairments that progress throughout the disease stages; however, little research has evaluated specific dual-task abilities in this' population, and the degree to which they may be related to functional ability.Objectives: The purpose of this study was to a) examine simple and complex motor-cognitive dual-task performance in individuals with HD, b) determine relationships between dual-task walking ability and disease-specific measures of motor, cognitive and functional ability, and c) examine the relationship of dual-task measures to falls in individuals with HD.Methods: Thirty-two individuals with HD were evaluated for simple and complex dual-task ability using the Walking While Talking Test. Demographics and disease-specific measures of motor, cognitive and functional ability were also obtained.Results: Individuals with HD had impairments in simple and complex dual-task ability. Simple dual-task walking was correlated to disease-specific motor scores as well as cognitive performance, but complex dual-task walking was correlated with total functional capacity, as well as a range of cognitive measures. Number of prospective falls was moderately-strongly correlated to dual-task measures.Conclusions: Our results, suggest that individuals with HD have impairments in cognitive-motor dual-task ability that are related to disease progression and specifically functional ability. Dual-task measures appear to evaluate a unique construct in individuals with early to mid-stage HD, and may have value in improving the prediction of falls risk in this population. (C) 2016 Elsevier B.V. All rights reserved.