Vagal afferent nerves with the properties of nociceptors.

Vagal afferent nerves with the properties of nociceptors.
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DOI:
10.1016/j.autneu.2009.08.001
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发表时间:
2010-02-16
期刊:
Autonomic neuroscience : basic & clinical
影响因子:
--
通讯作者:
Brozmanova M
Brozmanova M
中科院分区:
其他
文献类型:
--
作者:
Kollarik M;Ru F;Brozmanova M

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迷走传入神经对内脏器官的最佳神经调节至关重要,但通常不认为对内脏器官的防御很重要。然而,有明确定义的迷走传入神经亚群,它们具有特异性的激活特性,以检测潜在的有害刺激(伤害感受器)。迷走支气管肺c纤维在健康的肺中是静止的,但很容易被有毒化学物质和炎症分子激活。在食道中也发现了具有类似激活特性的迷走传入神经,并且可能存在于其他内脏组织中。此外,这些假定的迷走神经c -纤维经常启动防御性反射,可以敏化,并具有诱导中枢敏化的能力。这些特性是躯体组织中伤害感受器的特征。
Vagal afferent nerves are essential for optimal neural regulation of visceral organs, but are not often considered important for their defense. However, there are well-defined subsets of vagal afferent nerves that have activation properties indicative of specialization to detect potentially harmful stimuli (nociceptors). This is clearly exemplified by the vagal bronchopulmonary C-fibers that are quiescent in healthy lungs but are readily activated by noxious chemicals and inflammatory molecules. Vagal afferent nerves with similar activation properties have been also identified in the esophagus and probably exist in other visceral tissues. In addition, these putative vagal C-fibers often initiate defensive reflexes, can be sensitized, and have the capacity to induce central sensitization. This set of properties is characteristic of nociceptors in somatic tissues.
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发表时间: 2003-09-01
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