Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst
Direct asymmetric hydroxyamination reaction catalyzed by an axially chiral secondary amine catalyst
复制标题
DOI：
10.1021/ja0604515
复制
发表时间：
2006-05-10
影响因子：
15
通讯作者：
Maruoka, Keiji
中科院分区：
文献类型：
--
作者：
Kano, Taichi;Ueda, Mitsuhiro;Maruoka, Keiji
新型轴向手性仲胺催化剂（S）-1d催化醛与亚硝基苯的直接不对称羟胺化反应。所得的光学富集的羟基胺化产物容易地在一锅中转化为β-氨基醇或1，2-二胺。
A direct asymmetric hydroxyamination reaction of aldehydes with nitrosobenzene was found to be catalyzed by the novel axially chiral secondary amine catalyst (S)-1d. The resulting optically enriched hydroxyamination products were readily converted to β-amino alcohols or 1,2-diamines in one pot.