The outer frontier: the importance of lipid metabolism in the skin
The outer frontier: the importance of lipid metabolism in the skin
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DOI：
10.1194/jlr.r800039-jlr200
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发表时间：
2009-04-01
影响因子：
6.5
通讯作者：
Feingold, Kenneth R.
中科院分区：
文献类型：
--
作者：
Feingold, Kenneth R.
皮肤的重要功能是在恶劣的外部环境和宿主之间提供屏障。虽然皮肤具有许多重要的屏障功能，但对生存绝对重要的两个功能是水和电解质运动的屏障（渗透性屏障）和抵御侵入性和有毒微生物的屏障（抗菌屏障）。脂质在渗透性屏障和抗菌屏障的形成和维持中发挥着重要作用。角质层中的疏水性细胞外脂质基质主要由神经酰胺、胆固醇和游离脂肪酸组成，为水和电解质的运动提供屏障。多种脂质，例如脂肪醇、单甘油酯、鞘脂、磷脂，特别是游离脂肪酸，具有抗菌活性并有助于抗菌屏障。除了这些基本功能之外，我们还将回顾皮肤表面胆固醇反映全身脂质代谢变化和动脉粥样硬化风险的能力。-Feingold, K. R. 外部前沿：皮肤脂质代谢的重要性。 J.脂质研究。 2009.S417-S422。
The skin serves the vital function of providing a barrier between the hostile external environment and the host. While the skin has many important barrier functions, the two that are absolutely essential for survival are the barrier to the movement of water and electrolytes (permeability barrier) and the barrier against invasive and toxic microorganisms (antimicrobial barrier). Lipids play an essential role in the formation and maintenance of both the permeability and antimicrobial barriers. A hydrophobic extracellular lipid matrix in the stratum corneum composed primarily of ceramides, cholesterol, and free fatty acids provides the barrier to the movement of water and electrolytes. A variety of lipids, such as fatty alcohols, monoglycerides, sphingolipids, phospholipids, and in particular free fatty acids, have antimicrobial activity and contribute to the antimicrobial barrier. In addition to these essential functions, we will also review the ability of skin surface cholesterol to reflect alterations in systemic lipid metabolism and the risk of atherosclerosis.-Feingold, K. R. The outer frontier: the importance of lipid metabolism in the skin. J. Lipid Res. 2009. S417-S422.