Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction.
Log-transformed plasma level of brain natriuretic peptide during the acute phase of Kawasaki disease is quantitatively associated with myocardial dysfunction.
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DOI：
10.3345/kjp.2011.54.8.340
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发表时间：
2011-08
影响因子：
--
通讯作者：
Park IS
中科院分区：
文献类型：
--
作者：
Bang S;Yu JJ;Han MK;Ko HK;Chun S;Choi HS;Kim YH;Ko JK;Park IS
脑钠肽（BNP）被认为是川崎病心肌炎的生化标志物。我们进行这项研究是为了确定其定量意义。我们试图将81例川崎病患儿的对数转换BNP浓度（log-BNP）与临床、实验室和超声心动图变量联系起来。采用逐步多元线性回归分析确定与log-BNP浓度独立相关的变量。血清c反应蛋白水平（P<0.0001）、血清丙氨酸转氨酶浓度（P=0.0032）、白细胞计数（P=0.0030）、左室质量指数（P=0.0024）与log-BNP、血红蛋白水平（P<0.0001）、血清白蛋白水平（P<0.0001）、Na+浓度（P<0.0001）、左室缩短时间（P=0.0080）呈正相关。左室基底外侧段舒张早期组织速度峰值与log-BNP浓度呈显著负相关（P=0.0045）。多元回归分析显示，血清白蛋白浓度（R2=0.31， P=0.0098）和左心室质量指数（R2=0.09， P=0.0004）与log-BNP浓度显著相关。川崎病急性期BNP水平升高可能与心功能障碍相关，伴有左心室体积增大，log-BNP浓度可能是川崎病心肌炎的定量生化指标。
Brain natriuretic peptide (BNP) has been considered a biochemical marker for myocarditis in Kawasaki disease. We performed this study to determine its quantitative significance. We attempted to correlate log-transformed BNP concentrations (log-BNP) and clinical, laboratory, and echocardiographic variables in 81 children with Kawasaki disease. Stepwise multiple linear regression analysis was used to determine the variables independently associated with log-BNP concentration. Serum C-reactive protein level (P<0.0001), serum alanine aminotransferase concentration (P=0.0032), white blood cell count (P=0.0030), and left ventricular mass index (P=0.0024) were positively related with log-BNP, and hemoglobin level (P<0.0001), serum albumin level (P<0.0001), Na+ concentrations (P<0.0001), left ventricular fractional shortening (P=0.0080), and peak early diastolic tissue velocity of the left ventricular basal lateral segment (P=0.0045) were negatively related to the log-BNP concentration. Multiple regression analysis showed that serum albumin concentration (R2=0.31, P=0.0098) and left ventricular mass index (R2=0.09, P=0.0004) were significantly associated with the log-BNP concentration. Elevated BNP levels during the acute phase of Kawasaki disease may be attributable to cardiac dysfunction associated with the increase in left ventricular mass, and log-BNP concentration may be a quantitative biochemical marker of myocarditis in Kawasaki disease.