Optimization of patient-specific stereo-EEG recording sensitivity.
Optimization of patient-specific stereo-EEG recording sensitivity.
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DOI：
10.1093/braincomms/fcad304
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发表时间：
2023
影响因子：
4.8
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中科院分区：
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立体脑电图是一种微创技术，用于定位耐药性癫痫患者的癫痫活动起源（致痫区）。然而，目前的立体脑电轨迹规划方法是不可知的植入电极的空间记录灵敏度。在这项研究中，我们使用基于图像的患者特定的计算模型来设计优化的立体EEG电极配置。患者特定的优化电极配置显示出比临床植入配置高得多的记录灵敏度，这可能导致更准确地描绘致癫痫区。与临床植入配置相比，优化的配置还通过更少的电极实现了同样好或更好的记录灵敏度，这可能会降低并发症（包括颅内出血）的风险。这种方法通过将立体EEG的临床使用从离散的特设采样转换为感兴趣区域的智能映射来改善致痫区的定位。Dessert等人提供了第一种用于优化立体EEG规划的方法，该方法考虑了基于患者特定生物物理建模的空间记录灵敏度。与手动计划相比，优化的电极配置可以提高致痫区定位的安全性和有效性。
Stereo-EEG is a minimally invasive technique used to localize the origin of epileptic activity (the epileptogenic zone) in patients with drug-resistant epilepsy. However, current stereo-EEG trajectory planning methods are agnostic to the spatial recording sensitivity of implanted electrodes. In this study, we used image-based patient-specific computational models to design optimized stereo-EEG electrode configurations. Patient-specific optimized electrode configurations exhibited substantially higher recording sensitivity than clinically implanted configurations, and this may lead to a more accurate delineation of the epileptogenic zone. The optimized configurations also achieved equally good or better recording sensitivity with fewer electrodes compared with clinically implanted configurations, and this may reduce the risk for complications, including intracranial haemorrhage. This approach improves localization of the epileptogenic zone by transforming the clinical use of stereo-EEG from a discrete ad hoc sampling to an intelligent mapping of the regions of interest. Dessert et al. provide the first method for optimized stereo-EEG planning that considers spatial recording sensitivity based on patient-specific biophysical modelling. Optimized electrode configurations may improve both the safety and the efficacy of epileptogenic zone localization compared with manual planning.