Effects of α-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice
Effects of α-Galactooligosaccharides from Chickpeas on High-Fat-Diet-Induced Metabolic Syndrome in Mice
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DOI：
10.1021/acs.jafc.7b00489
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发表时间：
2017-04-19
影响因子：
6.1
通讯作者：
Zeng, Xiaoxiong
中科院分区：
文献类型：
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作者：
Dai, Zhuqing;Lyu, Wanyong;Zeng, Xiaoxiong
肠道微生物群具有调节宿主能量稳态的能力，这可能调节代谢紊乱。功能性低聚糖对肠道菌群有积极的调节作用。因此，从鹰嘴豆α-低聚半乳糖（α-GOS）对高脂饮食（HFD）诱导的代谢综合征和肠道菌群失调的影响进行了研究。干预6周后，与正常饲料喂养的小鼠相比，HFD导致小鼠的血糖、总胆固醇、甘油三酯、糖化血清蛋白、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇水平显著升高。同时，与HFD组相比，所有α-GOS治疗组的上述参数均显著降低。HFD能显著降低各细菌的含量，尤其是类杆菌（9.82 +/- 0.09对比10.3 +/- 0.10; p < 0.05）和乳酸杆菌（6.67 +/- 0.18对7.30 +/- 0.24; p < 0.05），还观察到短链脂肪酸的产生减少：用α-GOS处理显著增加了双歧杆菌（低剂量处理的6.07 +/-0.23对HFD组的5.65 +/-0.20）和乳酸杆菌（低剂量处理的7.22 +/-0.16）的数量。它还显着促进丙酸和丁酸的分泌。这些结果表明，鹰嘴豆α-GOS可能以积极的方式影响代谢紊乱和肠道细菌生态系统。
The gut microbiota has the ability to modulate host energy homeostasis, which may regulate metabolic disorders. Functional oligosaccharide may positively regulate the intestinal microbiota. Therefore, effects of alpha-galactooligosaccharides (alpha-GOS) from chickpea on high-fat-diet (HFD)-induced metabolic syndrome and gut bacterial dysbiosis were investigated. After 6 weeks of intervention, HFD led to significant increases in levels of blood glucose, total cholesterol, triglyceride, glycated serum protein, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol of mice compared to normal-chow-fed mice. Meanwhile, all of the alpha-GOS-treated groups significantly decreased above parameters compared to the HFD group. HFD could significantly decrease the content of all bacteria, especially Bacteroides (9.82 +/- 0.09 versus 10.3 +/- 0.10; p < 0.05) and Lactobacillus (6.67 +/- 0.18 versus 7.30 +/- 0.24; p < 0.05), and a decrease in the production of short-chain fatty acids was also observed: Treatment with a-GOS significantly increased the number of Bifidobacterium (6.07 +/- 0.23 of the low-dose treatment versus 5.65 +/- 0.20 of the HFD group) and Lactobacillus (7.22 +/- 0.16 of the low-dose treatment). It also significantly promoted the secretion of propionic and butyric acids. These results indicate that a-GOS from chickpeas may affect the metabolic disorders and gut bacterial ecosystem in a positive way.