Precancerous conditions of pancreatic carcinoma.
Precancerous conditions of pancreatic carcinoma.
复制标题
胰腺癌的癌前病变。
DOI：
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发表时间：
2000
期刊：
影响因子：
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通讯作者：
G. Klöppel
中科院分区：
文献类型：
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作者：
J. Lüttges;G. Klöppel
与胰腺导管癌相关的癌前状态包括癌前导管改变和引起导管癌的良性肿瘤。在被讨论为癌前病变的导管变化中，有增生性和化生性病变，最近被分类为胰腺上皮内瘤变1A、1B、2和3型。这一新系统与旧的术语进行了比较。最新的分子研究结果关于最常见的遗传变异的显性癌支持新的分类系统。非肿瘤性胰腺导管病变的相对频率及其与慢性胰腺炎和导管癌的关系进行了讨论。最后，胰腺外分泌肿瘤可能引起导管癌。
The precancerous conditions associated with pancreatic ductal carcinoma include preneoplastic duct changes and benign-looking tumors that give rise to ductal carcinomas. Among the duct changes that are discussed as precancerous lesions are hyperplastic and metaplastic lesions, which were recently classified as pancreatic intraepithelial neoplasia types 1A, 1B, 2, and 3. This new system is compared with the older terminology. Recent molecular findings concerning the most frequent genetic alterations in manifest carcinomas support the new classification system. The relative frequency of duct lesions in the nonneoplastic pancreas and their association with chronic pancreatitis and ductal carcinoma are discussed. Finally, the pancreatic exocrine tumors that may give rise to ductal carcinomas are presented.
DOI：
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发表时间：
1998-06
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
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作者：
P. G. Terhune;Dawnyale M. Phifer;T. Tosteson;D. Longnecker
通讯作者：
P. G. Terhune;Dawnyale M. Phifer;T. Tosteson;D. Longnecker
MUC2基因在非侵袭性肿瘤中发现表达，但在胰腺和肝脏的侵袭性肿瘤中不表达：其与患者的预后密切相关。
影响因子：
3.3
作者：
Yonezawa,S;Sueyoshi,K;Nomoto,M;Kitamura,H;Nagata,K;Arimura,Y;Tanaka,S;Hollingsworth,MA;Siddiki,B;Kim,YS;Sato,E
通讯作者：
Sato,E