Disparities in Chronic Kidney Disease Prevalence among Males and Females in 195 Countries: Analysis of the Global Burden of Disease 2016 Study
Disparities in Chronic Kidney Disease Prevalence among Males and Females in 195 Countries: Analysis of the Global Burden of Disease 2016 Study
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DOI：
10.1159/000489897
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发表时间：
2018-01-01
期刊：
影响因子：
2.5
通讯作者：
Remuzzi, Giuseppe
中科院分区：
文献类型：
--
作者：
Bikbov, Boris;Perico, Norberto;Remuzzi, Giuseppe
背景：慢性肾脏病（CKD）给卫生保健系统带来了巨大的负担。有一些特别脆弱的群体，CKD负担很高，其中之一是妇女。我们对195个国家所有CKD分期和肾脏替代治疗（定义为肾功能受损[IKF]）患病率的性别差异进行了分析。研究方法：我们使用了全球疾病负担（GBD）研究2016年修订版使用贝叶斯回归分析工具DisMoD-MR 2.1产生的估计值。根据人均购买力平价计算的国内生产总值数据是通过世界银行国际比较方案数据库获得的。为了估计性别差异，我们计算了每种IKF疾病的男性：女性全年龄患病率比率。结果：2016年，全球IKF患者人数达到7.527亿，其中女性4.170亿，男性3.357亿。两组中最常见的IKF形式是蛋白尿伴肾小球滤过率维持。地理空间分析显示，所有IKF条件下的男女比例分布非常不均匀，在肾移植患者中发现了最突出的对比。男性中位数：根据国内生产总值购买力平价五分位数的不同，女性比例差异很大;但是，经济状况不同的国家男女比例可能相似。国内生产总值购买力平价与透析移植ratio的强相关性found. Conclusions：GBD研究强调了195个国家中CKD患病率的显著性别差异。然而，这些差异的性质是复杂的，必须在考虑到所有可能情况的情况下谨慎解释。(C)2018 S. Karger AG，巴塞尔
Background: Chronic kidney disease (CKD) imposes a substantial burden on health care systems. There are some especially vulnerable groups with a high CKD burden, one of which is women. We performed an analysis of gender disparities in the prevalence of all CKD stages and renal replacement therapy (defined as impaired kidney function [IKF]) in 195 countries. Methods: We used estimates produced by the Global Burden of Disease (GBD) Study 2016 revision using a Bayesian-regression analytic tool, DisMoD-MR 2.1. Data on gross domestic product based on purchasing power parity per capita (GDP PPP) was obtained via the World Bank International Comparison Program database. To estimate gender disparities, we calculated the male: female all-age prevalence rate ratio for each IKF condition. Results: In 2016, the global number of individuals with IKF reached 752.7 million, including 417.0 million females and 335.7 million males. The most prevalent form of IKF in both groups was albuminuria with preserved glomerular filtration rate. Geospatial analysis shows a very heterogeneous distribution of the male: female ratio for all IKF conditions, with the most prominent contrast found in kidney transplant patients. The median male: female ratio varies substantially according to GDP PPP quintiles; however, countries with different economic states could have similar male: female ratios. A strong correlation of GDP PPP with dialysis-to-transplant ratio was found. Conclusions: The GBD study highlights the prominent gender disparities in CKD prevalence among 195 countries. The nature of these disparities, however, is complex and must be interpreted cautiously taking into account all possible circumstances. (C) 2018 S. Karger AG, Basel