Ion Selectivity in the ENaC/DEG Family: A Systematic Review with Supporting Analysis.
Ion Selectivity in the ENaC/DEG Family: A Systematic Review with Supporting Analysis.
复制标题
ENAC/DEG家族中的离子选择性：具有支持分析的系统评价。
DOI：
10.3390/ijms222010998
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发表时间：
2021-10-12
影响因子：
5.6
通讯作者：
Lewis R
中科院分区：
文献类型：
--
作者：
Vallée C;Howlin B;Lewis R
上皮钠通道/脱generin （Epithelial Sodium Channel/Degenerin, ENaC/DEG）家族是一个钠选择通道超家族，在多种动物物种中发挥着多种重要的生理作用。尽管它们存在差异，但它们在发生离子辨别的孔区具有高度的同源性。虽然离子选择性已经研究了几十年，但三聚体通道，特别是ENaC/DEG家族的这种选择性的机制仍然知之甚少。本系统综述遵循PRISMA指南，旨在确定ENaC/DEG家族中控制离子选择性的主要成分。根据特定的排除和纳入标准，共纳入了来自3个在线数据库的27篇论文。发现G/SxS选择性过滤器（甘氨酸/丝氨酸、非保守残基、丝氨酸）和其他保守良好的残基对离子选择性起着至关重要的作用。根据离子类型的不同，具有不同性质的残基参与离子渗透。对于锂对抗钠，选择性过滤器上游的芳香族残基似乎很重要，而对于钠对抗钾，选择性过滤器下游的负电荷残基似乎很重要。这一综述为进一步研究离子选择性机制提供了新的思路。
The Epithelial Sodium Channel/Degenerin (ENaC/DEG) family is a superfamily of sodium-selective channels that play diverse and important physiological roles in a wide variety of animal species. Despite their differences, they share a high homology in the pore region in which the ion discrimination takes place. Although ion selectivity has been studied for decades, the mechanisms underlying this selectivity for trimeric channels, and particularly for the ENaC/DEG family, are still poorly understood. This systematic review follows PRISMA guidelines and aims to determine the main components that govern ion selectivity in the ENaC/DEG family. In total, 27 papers from three online databases were included according to specific exclusion and inclusion criteria. It was found that the G/SxS selectivity filter (glycine/serine, non-conserved residue, serine) and other well conserved residues play a crucial role in ion selectivity. Depending on the ion type, residues with different properties are involved in ion permeability. For lithium against sodium, aromatic residues upstream of the selectivity filter seem to be important, whereas for sodium against potassium, negatively charged residues downstream of the selectivity filter seem to be important. This review provides new perspectives for further studies to unravel the mechanisms of ion selectivity.
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影响因子：
4.8
作者：
Carattino, MD;Sheng, SH;Kleyman, TR
通讯作者：
Kleyman, TR
影响因子：
3.4
作者：
GAO, J;CHOU, LW;AUERBACH, A
通讯作者：
AUERBACH, A
影响因子：
3.4
作者：
Favre, I;Moczydlowski, E;Schild, L
通讯作者：
Schild, L
DOI：
10.1073/pnas.83.2.508
发表时间：
1986-01-01
影响因子：
11.1
作者：
GUY, HR;SEETHARAMULU, P
通讯作者：
SEETHARAMULU, P
影响因子：
3.4
作者：
Furini, Simone;Domene, Carmen
通讯作者：
Domene, Carmen