Stress and anxious-related behaviors in Lurcher mutant mice
Stress and anxious-related behaviors in Lurcher mutant mice
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DOI：
10.1016/j.brainres.2004.01.008
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发表时间：
2004-04-02
期刊：
影响因子：
2.9
通讯作者：
Caston, J
中科院分区：
文献类型：
--
作者：
Hilber, P;Lorivel, T;Caston, J
在小脑Lurcher突变小鼠和对照小鼠完成高架十字迷宫测试之前和之后测量血液皮质酮水平（CORT）。与突变体中下丘脑-垂体-肾上腺（HPA）系统存在更明显的激活相一致，我们的研究结果表明，虽然突变体和对照组的基础CORT相似，但在完成焦虑行为测试后，Lurcher小鼠的应激指标激增。相比之下，在行为水平上，我们还观察到Lurcher表现出显著降低的焦虑相关指数;他们花了大量的时间在令人厌恶的地方的设备，并进入他们更频繁地比非突变小鼠。有人建议，而不是不那么焦虑，Lurcher小鼠被抑制比对照组时，放置在焦虑的情况下，这种不良的抑制可能是因果关系的HPA系统调节的变化。因此，我们的行为和内分泌结果的总体模式提供了证据，表明小脑回路参与了生理和行为应激相关情绪反应的变化。(C)2004 Elsevier B. V.保留所有权利。
Blood corticosterone levels (CORT) were measured before and after the completion of the elevated +-maze test in cerebellar Lurcher mutant and control mice. Consistent with the existence of a much more pronounced activation of the hypothalamo-pituitary-adrenal (HPA) system in the mutants, our results showed that while basal CORT were similar in mutants and controls, the surge of this stress indicator was enhanced in the Lurcher mice after completion of a behavioral test of anxiety. In contrast, at the behavioral level, we also observed that Lurcher exhibited significantly reduced anxiety related indices; they spent a significant greater amount of time in the aversive places of the apparatus and entered them more frequently than non mutant mice. It is proposed that rather than less anxious, the Lurcher mice are less inhibited than controls when placed in anxiogenic situation and that such poor inhibition could be causally related to changes in HPA system regulation. The overall patterns of our behavioral and endocrinological results thereby provided the evidence that cerebellar circuitry is involved in producing changes in physiological and behavioral stress-related emotional responses. (C) 2004 Elsevier B.V. All rights reserved.