Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
Porous metal-organic-framework nanoscale carriers as a potential platform for drug delivery and imaging
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DOI：
10.1038/nmat2608
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发表时间：
2010-02-01
期刊：
影响因子：
41.2
通讯作者：
Gref, Ruxandra
中科院分区：
文献类型：
--
作者：
Horcajada, Patricia;Chalati, Tamim;Gref, Ruxandra
在健康领域，一个重要的挑战是使用无毒的纳米载体在体内高效地输送药物。大多数现有的载体材料表现出较差的载药量(通常小于所传输药物相对于载体材料的5wt%)和/或简单地吸附(或锚定)在纳米载体外表面的药物的快速释放比例。在这种情况下，多孔性杂化固体具有调节其结构和孔隙率以实现更好的药物相互作用和高负载的能力，非常适合作为纳米载体用于输送和成像应用。在这里，我们展示了具有工程核心和表面的特定无毒多孔铁(III)金属-有机骨架以及成像性能，作为高效控制输送具有挑战性的抗肿瘤和逆转录病毒药物(即丁硫丹、叠氮胸苷三磷酸、阿霉素或西多福韦)的卓越纳米载体。除了高负荷外，它们还可能将治疗学和诊断学联系起来，从而为治疗或个性化患者治疗开辟了道路。
In the domain of health, one important challenge is the efficient delivery of drugs in the body using non-toxic nanocarriers. Most of the existing carrier materials show poor drug loading (usually less than 5 wt% of the transported drug versus the carrier material) and/or rapid release of the proportion of the drug that is simply adsorbed (or anchored) at the external surface of the nanocarrier. In this context, porous hybrid solids, with the ability to tune their structures and porosities for better drug interactions and high loadings, are well suited to serve as nanocarriers for delivery and imaging applications. Here we show that specific non-toxic porous iron(III)-based metal-organic frameworks with engineered cores and surfaces, as well as imaging properties, function as superior nanocarriers for efficient controlled delivery of challenging antitumoural and retroviral drugs (that is, busulfan, azidothymidine triphosphate, doxorubicin or cidofovir) against cancer and AIDS. In addition to their high loadings, they also potentially associate therapeutics and diagnostics, thus opening the way for theranostics, or personalized patient treatments.